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机器人二尖瓣修复治疗简单和复杂退行性疾病:中期临床和超声心动图质量结果。

Robotic Mitral Valve Repair for Simple and Complex Degenerative Disease: Midterm Clinical and Echocardiographic Quality Outcomes.

机构信息

From Divisions of Cardiovascular Surgery (R.M.S., A.T., H.M.B., R.C.D., J.A.D.), Anesthesiology (W.M.), Cardiovascular Diseases (R.A.N., H.I.M., M.E.-S.), and Biomedical Statistics and Informatics (Z.L.), Mayo Clinic, Rochester, MN.

出版信息

Circulation. 2015 Nov 24;132(21):1961-8. doi: 10.1161/CIRCULATIONAHA.115.017792. Epub 2015 Oct 19.

Abstract

BACKGROUND

Severe primary (degenerative) mitral regurgitation (MR) is repaired with durable results when simple single-scallop disease is addressed. The midterm quality outcomes of minimally invasive repair for complex disease are unknown, however.

METHODS AND RESULTS

From January 2008 to January 2015, 487 patients (56±11 years, 360 men, ejection fraction 65±6%, 98.8% complete follow-up) underwent robotic mitral valve repair for severe nonischemic degenerative MR. Simple pathology was addressed in 289 of 487 (59%) patients, and complex repair (all others) was performed in 198 of 487 (41%). Four patients died during follow-up with a 5-year survival rate 99.5% (99.4% simple; 99.5% complex; hazard ratio, 0.48; 95% confidence interval, 0.05-4.59); and New York Heart Association functional class I/II was documented in 97.9% (477/487). Eight patients had recurrence of moderate-to-severe MR (4 simple, 4 complex), with a 5-year freedom from MR of 94.6% (96.2% simple; 92.7%, complex; P=0.67; hazard ratio, 1.36; 95% confidence interval, 0.34-5.43). Seven patients (2 simple, 5 complex), underwent mitral reoperation, with a 5-year freedom from reoperation of 97.7% (99.1% simple; 95.7% complex; P=0.13; hazard ratio, 3.35; 95% confidence interval, 0.65-17.32).

CONCLUSIONS

At a large tertiary care referral center, midterm quality outcomes after robotic correction of degenerative MR are excellent, with very high survival, infrequent complications, and a low likelihood of MR recurrence, regardless of mitral valve repair complexity. Awareness of these improvements in outcome is important to inform contemporary decisions regarding high-quality alternatives to conventional and percutaneous mitral repair.

摘要

背景

当简单的单瓣叶病变得到解决时,严重原发性(退行性)二尖瓣反流(MR)可通过持久的修复获得良好效果。然而,微创修复复杂疾病的中期质量结果尚不清楚。

方法和结果

从 2008 年 1 月至 2015 年 1 月,487 例(56±11 岁,360 例男性,射血分数 65±6%,98.8%完成随访)患者接受机器人二尖瓣修复术治疗严重非缺血性退行性 MR。487 例患者中 289 例(59%)有简单病变,198 例(41%)行复杂修复(其他所有)。随访期间有 4 例患者死亡,5 年生存率为 99.5%(单纯组 99.4%;复杂组 99.5%;危险比 0.48;95%置信区间 0.05-4.59);97.9%(477/487)患者纽约心脏协会心功能分级为Ⅰ/Ⅱ级。8 例患者出现中重度 MR 复发(4 例单纯,4 例复杂),5 年无 MR 生存率为 94.6%(单纯组 96.2%;复杂组 92.7%;P=0.67;危险比 1.36;95%置信区间 0.34-5.43)。7 例患者(2 例单纯,5 例复杂)行二尖瓣再手术,5 年无再手术生存率为 97.7%(单纯组 99.1%;复杂组 95.7%;P=0.13;危险比 3.35;95%置信区间 0.65-17.32)。

结论

在大型三级医疗中心,机器人矫正退行性 MR 的中期质量结果非常出色,生存率高,并发症少,MR 复发的可能性低,与二尖瓣修复的复杂性无关。了解这些结果的改善对于告知有关高质量替代传统和经皮二尖瓣修复的当代决策非常重要。

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