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氧化铁作为用于细胞追踪的磁共振成像造影剂

Iron Oxide as an MRI Contrast Agent for Cell Tracking.

作者信息

Korchinski Daniel J, Taha May, Yang Runze, Nathoo Nabeela, Dunn Jeff F

机构信息

Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. ; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

出版信息

Magn Reson Insights. 2015 Oct 6;8(Suppl 1):15-29. doi: 10.4137/MRI.S23557. eCollection 2015.

DOI:10.4137/MRI.S23557
PMID:26483609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4597836/
Abstract

Iron oxide contrast agents have been combined with magnetic resonance imaging for cell tracking. In this review, we discuss coating properties and provide an overview of ex vivo and in vivo labeling of different cell types, including stem cells, red blood cells, and monocytes/macrophages. Furthermore, we provide examples of applications of cell tracking with iron contrast agents in stroke, multiple sclerosis, cancer, arteriovenous malformations, and aortic and cerebral aneurysms. Attempts at quantifying iron oxide concentrations and other vascular properties are examined. We advise on designing studies using iron contrast agents including methods for validation.

摘要

氧化铁造影剂已与磁共振成像相结合用于细胞追踪。在本综述中，我们讨论了涂层特性，并概述了不同细胞类型（包括干细胞、红细胞和单核细胞/巨噬细胞）的体外和体内标记。此外，我们还提供了铁造影剂在中风、多发性硬化症、癌症、动静脉畸形以及主动脉和脑动脉瘤中进行细胞追踪应用的实例。对量化氧化铁浓度和其他血管特性的尝试进行了研究。我们就使用铁造影剂设计研究提供建议，包括验证方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/94df0a9b627e/mri-suppl.1-2015-015f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/9e1c9144e0ac/mri-suppl.1-2015-015f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/62b097a07f9a/mri-suppl.1-2015-015f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/e8dd4141e687/mri-suppl.1-2015-015f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/9da875e85cd5/mri-suppl.1-2015-015f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/94df0a9b627e/mri-suppl.1-2015-015f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/9e1c9144e0ac/mri-suppl.1-2015-015f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/62b097a07f9a/mri-suppl.1-2015-015f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/e8dd4141e687/mri-suppl.1-2015-015f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/9da875e85cd5/mri-suppl.1-2015-015f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/4597836/94df0a9b627e/mri-suppl.1-2015-015f5.jpg

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本文引用的文献

[1]
Hydrophilic packaging of iron oxide nanoclusters for highly sensitive imaging.

Biomaterials. 2015-11

[2]
Magnetic Resonance Imaging of Atherosclerosis Using CD81-Targeted Microparticles of Iron Oxide in Mice.

Biomed Res Int. 2015

[3]
Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool.

Int J Nanomedicine. 2015-7-28

[4]
Superparamagnetic iron oxide nanoparticles for direct labeling of stem cells and in vivo MRI tracking.

Contrast Media Mol Imaging. 2016

[5]
In vitro hematological and in vivo immunotoxicity assessment of dextran stabilized iron oxide nanoparticles.

Colloids Surf B Biointerfaces. 2015-10-1

[6]
Flow cytometry for intracellular SPION quantification: specificity and sensitivity in comparison with spectroscopic methods.

Int J Nanomedicine. 2015-6-26

[7]
Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment.

Nanoscale. 2015-8-7

[8]
Determination of blood circulation times of superparamagnetic iron oxide nanoparticles by T2* relaxometry using ultrashort echo time (UTE) MRI.

Magn Reson Imaging. 2015-11

[9]
Impact of magnetic field parameters and iron oxide nanoparticle properties on heat generation for use in magnetic hyperthermia.

J Magn Magn Mater. 2015-8-1

[10]
Superparamagnetic iron oxide nanoparticles for in vivo molecular and cellular imaging.

Contrast Media Mol Imaging. 2015

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