用于高效生成产生靶蛋白细胞系的载体中的调控元件。
Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins.
作者信息
Maksimenko O, Gasanov N B, Georgiev P
机构信息
Institute of Gene Biology, Russian Academy of Sciences, Vavilova str. 34/5, 119334, Moscow, Russia.
出版信息
Acta Naturae. 2015 Jul-Sep;7(3):15-26.
Abstract
To date, there has been an increasing number of drugs produced in mammalian cell cultures. In order to enhance the expression level and stability of target recombinant proteins in cell cultures, various regulatory elements with poorly studied mechanisms of action are used. In this review, we summarize and discuss the potential mechanisms of action of such regulatory elements.
摘要
迄今为止，在哺乳动物细胞培养物中生产的药物数量一直在增加。为了提高细胞培养物中目标重组蛋白的表达水平和稳定性，人们使用了各种作用机制研究较少的调控元件。在这篇综述中，我们总结并讨论了此类调控元件的潜在作用机制。
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