Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia.
作者信息
Sun Li, Cheng Zaohuo, Zhang Fuquan, Xu Yong
机构信息
Wuxi Mental Health Center of Nanjing Medical University, Wuxi, Jiangsu Province, China.
Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China.
出版信息
Genom Data. 2015 Jun 9;5:169-70. doi: 10.1016/j.gdata.2015.04.022. eCollection 2015 Sep.
Abstract
Schizophrenia (SZ) is a severe chronic psychiatric disorder with wide prevalence and high morbidity. We know little about SZ's etiology and pathophysiology at present. The study of gene expression profile is useful for us to identify potential biomarkers at molecular level and explain possible pathogenesis of SZ. Therefore we recently compared gene expression profiles in PMBCs from EOS cases and healthy controls using microarrays. Here we will describe in detail the contents and quality control of the microarray experiment. The raw microarray data are accessible through GEO series accession number GSE54913.
摘要
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本文引用的文献
1
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Mol Biol Rep. 2013 Aug;40(8):5123-8. doi: 10.1007/s11033-013-2614-3. Epub 2013 May 11.
2
A systematic review of the long-term outcome of early onset schizophrenia.一项关于早发性精神分裂症长期预后的系统回顾。
BMC Psychiatry. 2012 Sep 19;12:150. doi: 10.1186/1471-244X-12-150.
3
Finding the needle in the haystack: a review of microarray gene expression research into schizophrenia.大海捞针：精神分裂症的基因表达微阵列研究综述。
Aust N Z J Psychiatry. 2012 Jul;46(7):598-610. doi: 10.1177/0004867412442405. Epub 2012 Mar 22.
4
Neurodevelopmental hypothesis of schizophrenia.精神分裂症的神经发育假说。
Br J Psychiatry. 2011 Mar;198(3):173-5. doi: 10.1192/bjp.bp.110.084384.
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Analyzing schizophrenia by DNA microarrays.用 DNA 微阵列分析精神分裂症。
Biol Psychiatry. 2011 Jan 15;69(2):157-62. doi: 10.1016/j.biopsych.2010.07.017.
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