近红外介导的细胞靶向中空金纳米颗粒中一氧化氮的细胞内解笼效应
Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles.
作者信息
Levy Elizabeth S, Morales Demosthenes P, Garcia John V, Reich Norbert O, Ford Peter C
机构信息
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106-9510 USA.
出版信息
Chem Commun (Camb). 2015 Dec 28;51(100):17692-5. doi: 10.1039/c5cc07989f.
We demonstrate modulation of nitric oxide release in solution and in human prostate cancer cells from a thiol functionalized cupferron (TCF) absorbed on hollow gold nanoshells (HGNs) using near-infrared (NIR) light. NO release from the TCF-HGN conjugates occurs through localized surface heating due to NIR excitation of the surface plasmon. Specific HGN targeting is achieved through cell surface directed peptides, and excitation with tissue penetrating NIR light provides unprecedented spatio-temporal control of NO delivery to biological targets.
我们展示了利用近红外（NIR）光对吸附在中空金纳米壳（HGN）上的硫醇功能化铜铁试剂（TCF）在溶液和人前列腺癌细胞中一氧化氮释放的调控。由于表面等离子体的近红外激发，通过局部表面加热，TCF-HGN 共轭物释放一氧化氮。通过细胞表面导向肽实现对 HGN 的特异性靶向，并且用可穿透组织的近红外光激发可实现对一氧化氮输送到生物靶点的前所未有的时空控制。
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