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丝虫感染期间白细胞介素19和白细胞介素24对CD4 +和CD8 + T细胞功能的调节

Modulation of CD4+ and CD8+ T-Cell Function by Interleukin 19 and Interleukin 24 During Filarial Infections.

作者信息

Anuradha Rajamanickam, Munisankar Saravanan, Dolla Chandrakumar, Kumaran Paul, Nutman Thomas B, Babu Subash

机构信息

National Institutes of Health (NIH)-National Institute for Research in Tuberculosis (NIRT)-International Center for Excellence in Research.

NIRT, Chennai, India.

出版信息

J Infect Dis. 2016 Mar 1;213(5):811-5. doi: 10.1093/infdis/jiv497. Epub 2015 Oct 20.

DOI:10.1093/infdis/jiv497
PMID:26486636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4747619/
Abstract

Interleukin 19 (IL-19) and interleukin 24 (IL-24) are cytokines that are highly expressed in filarial infections. To study the role of IL-19 and IL-24 in regulating T-cell responses, we examined the frequency of T-helper type 1 (Th1)/Tc1, Th2/Tc2, Th9/Tc9, Th17/Tc17, Th22/Tc22, and Tr1 cells in 26 filariae-infected individuals stimulated with filarial antigen following IL-19 or IL-24 neutralization. IL-19 or IL-24 neutralization resulted in significantly enhanced frequencies of Th1/Tc1 and/or Th17/Tc17 cells and significantly reduced frequencies of Th2/Tc2, Tr1, and/or Th9/Tc9 cells. Thus, we demonstrate that IL-19 and IL-24 are associated with the modulation of T-cell responses in filarial infections.

摘要

白细胞介素19（IL-19）和白细胞介素24（IL-24）是在丝虫感染中高表达的细胞因子。为了研究IL-19和IL-24在调节T细胞反应中的作用，我们检测了26名丝虫感染个体在IL-19或IL-24中和后用丝虫抗原刺激时，1型辅助性T细胞（Th1）/1型细胞毒性T细胞（Tc1）、2型辅助性T细胞（Th2）/2型细胞毒性T细胞（Tc2）、9型辅助性T细胞（Th9）/9型细胞毒性T细胞（Tc9）、17型辅助性T细胞（Th17）/17型细胞毒性T细胞（Tc17）、22型辅助性T细胞（Th22）/22型细胞毒性T细胞（Tc22）和1型调节性T细胞（Tr1）的频率。IL-19或IL-24中和导致Th1/Tc1和/或Th17/Tc17细胞频率显著增加，Th2/Tc2、Tr1和/或Th9/Tc9细胞频率显著降低。因此，我们证明IL-19和IL-24与丝虫感染中T细胞反应的调节有关。

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