多核化是原位多形性小叶癌诊断中一项有用的客观特征。

Multinucleation is an objective feature useful in the diagnosis of pleomorphic lobular carcinoma in situ.

作者信息

Blanco Luis Z, Thurow Tiffany A, Mahajan Aparna, Susnik Barbara, Helenowski Irene, Chmiel Joan S, Sullivan Megan E

机构信息

From the Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL;

Department of Pathology, Abbott-Northwestern Hospital, Minneapolis, MN and.

出版信息

Am J Clin Pathol. 2015 Nov;144(5):722-6. doi: 10.1309/AJCPZHZ2TUE2UYNV.

DOI:10.1309/AJCPZHZ2TUE2UYNV

PMID:26486735

Abstract

OBJECTIVES

Bi- and multinucleated (B/M) cells are present in a variety of tumors. We evaluated lobular carcinoma in situ (classic and pleomorphic types) and ductal carcinoma in situ (DCIS) to determine if this objective morphologic feature aids the differential diagnosis.

METHODS

The number of B/M cells was recorded in pleomorphic lobular carcinoma in situ (PLCIS) (n = 20), classic lobular carcinoma in situ (CLCIS) (n = 26), and DCIS (n = 37).

RESULTS

Binucleated cells were significantly more frequent in PLCIS (100%) vs DCIS (43%; P < .0001) and CLCIS (54%; P = .0004). Multinucleated cells were present in 25% of PLCIS cases and 8% of DCIS cases, and they were absent in CLCIS. The quantity of B/M per high-power field (hpf) was less in DCIS (mean, 1.1) and CLCIS (mean, 2.5) compared with PLCIS (mean, 5.8). Thirty-five percent of PLCIS cases had more than five B/M per hpf.

CONCLUSIONS

Binucleated cells are significantly more frequent in PLCIS vs CLCIS and DCIS. Multinucleated cells were never identified in CLCIS. PLCIS should be considered as a diagnosis when B/M is noted.

摘要

目的

双核及多核（B/M）细胞存在于多种肿瘤中。我们评估了小叶原位癌（经典型和多形型）及导管原位癌（DCIS），以确定这一客观形态学特征是否有助于鉴别诊断。

方法

记录多形性小叶原位癌（PLCIS）（n = 20）、经典小叶原位癌（CLCIS）（n = 26）和DCIS（n = 37）中B/M细胞的数量。

结果

PLCIS中双核细胞的出现频率显著高于DCIS（43%；P <.0001）和CLCIS（54%；P =.0004），分别为100%。25%的PLCIS病例存在多核细胞，8%的DCIS病例存在多核细胞，而CLCIS中不存在多核细胞。与PLCIS（平均5.8个）相比，DCIS（平均1.1个）和CLCIS（平均2.5个）每高倍视野（hpf）的B/M细胞数量较少。35%的PLCIS病例每hpf有超过5个B/M细胞。