Thiele C, Theiss W, Kurfürst-Seebauer R
Vasa. 1989;18(1):48-55.
68 patients who underwent fibrinolytic treatment due to deep vein thrombosis of the lower extremity were followed-up after a median time interval of 6.3 years. Phlebography was carried out in all patients prior to and following fibrinolytic treatment. 28% of all patients showed complete patency and 38% partial patency. 34% showed no improvement. For the long term follow-up, physical examination, doppler-sonography, phlebodynamometry and vein occlusion plethysmography were assessed. The acute intervention, regarding treatment, turned out to be the crucial prognostic parameter. While late symptoms and clinical findings on the one hand and site, extent and age of thrombosis prior to fibrinolytic treatment on the other hand did not correlate with one another, symptoms and clinical findings did indeed correlate quite well with the outcome of fibrinolytic treatment. Postthrombotic syndrom was rare in cases with complete patency. In cases where patency was only partially or not at all achieved, postthrombotic syndrom was present to a higher degree the more central and the more extensive the remaining thrombosis was.
68例因下肢深静脉血栓形成接受纤维蛋白溶解治疗的患者，在中位时间间隔6.3年后进行了随访。所有患者在纤维蛋白溶解治疗前后均进行了静脉造影。所有患者中28%显示完全通畅，38%显示部分通畅。34%无改善。对于长期随访，评估了体格检查、多普勒超声、静脉压力测定和静脉阻塞体积描记法。结果表明，关于治疗的急性干预是关键的预后参数。一方面，晚期症状和临床发现与另一方面纤维蛋白溶解治疗前血栓形成的部位、范围和年龄之间没有相关性，但症状和临床发现确实与纤维蛋白溶解治疗的结果有很好的相关性。在完全通畅的病例中，血栓形成后综合征很少见。在通畅仅部分或根本未实现的病例中，剩余血栓越靠近中心且范围越广，血栓形成后综合征的程度越高。
