Chu Shuyuan, Yu Hongping, Chen Yan, Chen Qian, Wang Bin, Zhang Jun
MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; School of Public Health, Guilin Medical University, Guilin, 541004, China.
School of Public Health, Guilin Medical University, Guilin, 541004, China.
PLoS One. 2015 Oct 21;10(10):e0140443. doi: 10.1371/journal.pone.0140443. eCollection 2015.
Previous studies suggest that maternal antibiotics exposure during pregnancy may increase the risk of childhood asthma, but the results were inconsistent. Furthermore, most studies did not examine periconception period as an exposure window. We aim to assess the associations between maternal exposure to specific antibiotics before and during pregnancy and the risk of asthma in early childhood.
Data from the Collaborative Perinatal Project were used. Maternal exposure to antibiotics before and during pregnancy was recorded at each prenatal visit. A total of 39,907 singleton children were followed up to 7 years of age. Multilevel multiple logistic regression models were used to control for potential confounders and account for multiple pregnancies per woman.
Maternal use of penicillin or chloramphenicol was associated with an increased risk of asthma in the offspring (adjusted odds ratio = 1.21, 95% confidence interval 1.08-1.36 for penicillin; 1.72 [1.14-2.59] for chloramphenicol). The risk was significantly increased if penicillin or chloramphenicol was used in the 1st trimester (1.09 [1.04-1.13] for penicillin and 1.23 [1.01-1.51] for chloramphenicol).
Maternal exposure to certain antibiotics is associated with childhood asthma by 7 years of age. Early pregnancy may be a sensitive window.
先前的研究表明，孕期母亲接触抗生素可能会增加儿童患哮喘的风险，但结果并不一致。此外，大多数研究并未将受孕前后时期作为暴露窗口进行考察。我们旨在评估孕期及孕前母亲接触特定抗生素与儿童早期哮喘风险之间的关联。
使用围产期协作项目的数据。在每次产前检查时记录母亲在孕期及孕前接触抗生素的情况。对总共39907名单胎儿童进行随访至7岁。采用多水平多重逻辑回归模型来控制潜在混杂因素，并考虑每位女性的多次妊娠情况。
母亲使用青霉素或氯霉素与后代患哮喘风险增加相关（调整后的优势比：青霉素为1.21，95%置信区间为1.08 - 1.36；氯霉素为1.72 [1.14 - 2.59]）。如果在孕早期使用青霉素或氯霉素，风险会显著增加（青霉素为1.09 [1.04 - 1.13]，氯霉素为1.23 [1.01 - 1.51]）。
母亲接触某些抗生素与7岁儿童患哮喘有关。孕早期可能是一个敏感窗口。
