镍/铜催化的氟代芳烃脱氟硼化反应用于多样化的 C-F 键功能化。
Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations.
机构信息
Chemical Biology Team, Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
出版信息
J Am Chem Soc. 2015 Nov 18;137(45):14313-8. doi: 10.1021/jacs.5b10119. Epub 2015 Nov 3.
PMID:26488683
Abstract
Ni/Cu-catalyzed transformation of fluoroarenes to arylboronic acid pinacol esters via C-F bond cleavage has been achieved. Further versatile derivatization of an arylboronic ester has allowed for the facile two-step conversion of a fluoroarene to diverse functionalized arenes, demonstrating the synthetic utility of the method.
摘要
镍/铜催化氟代芳烃 C-F 键断裂转化为芳基硼酸频哪醇酯已经实现。芳基硼酸频哪醇酯的进一步多功能衍生化使得从氟代芳烃到多种官能化芳烃的两步转化变得容易，证明了该方法的合成实用性。
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