Whibley Natasha, Gaffen Sarah L
Kennedy Institute of Rheumatology, University of Oxford, Oxford, OX3 7FY, UK.
Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh PA 15261, USA.
Immunity. 2015 Oct 20;43(4):620-2. doi: 10.1016/j.immuni.2015.10.001.
Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes. Whereas antibodies targeting IL-23 ameliorate colitis, IL-17 neutralization exacerbates disease. In this issue, Cua and colleagues and Maxwell and colleagues show that IL-17 maintains intestinal barrier integrity, helping explain this dichotomy (Lee et al., 2015; Maxwell et al., 2015).
白细胞介素-23（IL-23）被认为是淋巴细胞中IL-17的关键调节因子。尽管靶向IL-23的抗体可改善结肠炎，但中和IL-17却会加重疾病。在本期杂志中，库阿及其同事以及麦克斯韦及其同事表明，IL-17可维持肠道屏障的完整性，这有助于解释这种矛盾现象（李等人，2015年；麦克斯韦等人，2015年）。
