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[一例酷似原发性肺癌的堪萨斯分枝杆菌肺病手术病例]

[A SURGICAL CASE OF MYCOBACTERIUM KANSASII LUNG DISEASE MIMICKING PRIMARY LUNG CANCER].

作者信息

Yamanaka Sumitaka, Tomoyasu Hiroshi

出版信息

Kekkaku. 2015 Apr;90(4):475-9.

PMID:26489151
Abstract

We report a rare surgical case of a solitary pulmonary nodule due to Mycobacterium kansasii. A 59-year-old man was admitted to our hospital for examination of an abnormal shadow in the left upper lobe incidentally found on a chest radiogram. Computed tomography of the chest showed that the nodule was located in the left segment 1+2 and was irregularly shaped with a diameter of 35 mm. Thoracic fluorine-18 fluoro-deoxy-glucose positron emission tomography showed a high metabolic pulmonary lesion, with a maximum standardized uptake value of 5.1, consistent with findings for lung cancer. A bronchoscopy was performed to establish the diagnosis of lung cancer; however, it failed to show malignant cells. Because we could not confirm the diagnosis by bronchoscopic examination, video-assisted thoracoscopic surgery was performed. The intraoperative rapid diagnosis of the nodule was epithelioid cell granuloma. Smear test of the resected specimen was positive for acid-fast bacilli, and a culture was also positive for mycobacteria, which were identified as Mycobacterium kansasii. Antibiotic treatment for M. kansasii infection was administered for a year after the surgical resection. Few cases of Mycobacterium kansasii infection present with solitary pulmonary nodules.

摘要

我们报告一例罕见的因堪萨斯分枝杆菌导致的孤立性肺结节手术病例。一名59岁男性因胸部X线片偶然发现左上叶异常阴影而入院。胸部计算机断层扫描显示结节位于左1 + 2段,形状不规则,直径35毫米。胸部氟-18氟脱氧葡萄糖正电子发射断层扫描显示肺部病变代谢高,最大标准化摄取值为5.1,与肺癌表现一致。为明确肺癌诊断进行了支气管镜检查;然而,未发现恶性细胞。由于通过支气管镜检查无法确诊,遂进行了电视辅助胸腔镜手术。术中对结节的快速诊断为上皮样细胞肉芽肿。切除标本的涂片检查抗酸杆菌呈阳性,培养也显示分枝杆菌阳性,鉴定为堪萨斯分枝杆菌。手术切除后给予了为期一年的针对堪萨斯分枝杆菌感染的抗生素治疗。很少有堪萨斯分枝杆菌感染表现为孤立性肺结节。

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