Cheng Yi-Shing Lisa, Rees Terry, Wright John
Tex Dent J. 2015 Aug;132(8):538-49.
The 5-year survival rate for oral cancer (66%) is still one of the lowest among major human cancers, and delayed diagnosis until an advanced stage is thought to be the main factor contributing to this low survival rate. The detection and diagnosis of oral cancer is currently based on clinical visual examination and histopathological evaluation of a biopsy specimen. In response to the need for early detection of oral cancer, several diagnostic adjuncts have been developed and sold commercially over the years, including vital tissue staining, brush cytology, light-based visualization adjuncts, and the most recently developed test for salivary biomarkers for oral cancer. The purpose of this article is to review the current knowledge and research regarding these diagnostic adjuncts developed for early detection of oral cancer. Clinicians are best served by an awareness of the advantages and disadvantages of each adjunct, and to always consider and correlate with the clinical findings when interpreting the test results from these adjuncts.
口腔癌的5年生存率（66%）仍是主要人类癌症中最低的之一，而直到晚期才被诊断被认为是导致这种低生存率的主要因素。目前口腔癌的检测和诊断基于临床视觉检查和活检标本的组织病理学评估。为满足口腔癌早期检测的需求，多年来已开发出多种诊断辅助手段并在市场上销售，包括活体组织染色、刷片细胞学检查、基于光的可视化辅助手段，以及最新开发的口腔癌唾液生物标志物检测。本文旨在综述目前有关这些为早期检测口腔癌而开发的诊断辅助手段的知识和研究。临床医生最好了解每种辅助手段的优缺点，并在解读这些辅助手段的检测结果时始终结合临床发现进行综合考量。
