伽玛刀放射外科治疗松果体区肿瘤：147例研究
Gamma knife radiosurgery (GKRS) for pineal region tumors: a study of 147 cases.
作者信息
Li Wentao, Zhang Binfei, Kang Wenxing, Dong Boning, Ma Xudong, Song Jinning, Liu Yonghong, Liang Zhenqiang
机构信息
Department of Neurosurgery, the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, #277, Yantaxi Rd, Xi'an, 710061, China.
Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710054, China.
出版信息
World J Surg Oncol. 2015 Oct 21;13:304. doi: 10.1186/s12957-015-0720-5.
BACKGROUND
The purpose of this study is to evaluate the effectiveness of gamma knife radiosurgery (GKRS) in the treatment of pineal region tumors (PRTs).
METHODS
We retrospectively reviewed 147 cases of PRTs primarily treated with GKRS at our hospital between 1999 and 2009. Mean follow-up time was 67 months (range 60.5-100.1). The local tumor control rates (LTCRs) and overall survival rates were calculated to evaluate the results of the GKRS treatment.
RESULTS
At 2 months after GKRS, tumor volume was significantly reduced in 91 cases (61.9%). At 6 months, average tumor volume was 4.2 cm(3) as compared to 8.47 cm(3) before GKRS. By 1 year after GKRS, the tumor completely disappeared in 57 patients. Fourteen patients underwent second treatment, and one patient had third treatment. The overall survival rates were 72.1% at 3 years and 66.7% at 5 years for all patients and 62.4% at 3 years and 54.5% at 5 years for germ cell tumors (GCTs). The LTCRs were 94.30% at 3 years and 90.80% at 5 years for all patients and 88.00% at 3 years and 77.27% at 5 years for GCTs.
CONCLUSIONS
GKRS is an effective and safe modality that can be widely used to PRTs as the primary therapy.
背景
本研究旨在评估伽玛刀放射外科治疗（GKRS）松果体区肿瘤（PRTs）的有效性。
方法
我们回顾性分析了1999年至2009年在我院主要接受GKRS治疗的147例PRTs患者。平均随访时间为67个月（范围60.5 - 100.1个月）。计算局部肿瘤控制率（LTCRs）和总生存率以评估GKRS治疗效果。
结果
GKRS治疗后2个月，91例（61.9%）患者肿瘤体积显著缩小。6个月时，平均肿瘤体积为4.2 cm³，而GKRS治疗前为8.47 cm³。到GKRS治疗后1年，57例患者肿瘤完全消失。14例患者接受了二次治疗，1例患者接受了三次治疗。所有患者3年总生存率为72.1%，5年为66.7%；生殖细胞肿瘤（GCTs）患者3年总生存率为62.4%，5年为54.5%。所有患者3年LTCRs为94.30%，5年为90.80%；GCTs患者3年LTCRs为88.00%，5年为77.27%。
结论
GKRS是一种有效且安全的治疗方式，可作为PRTs的主要治疗方法广泛应用。
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