Anczuków Olga, Krainer Adrian R
Cold Spring Harbor Laboratory, Bungtown Road, Cold Spring Harbor, NY, 11724, USA.
Genome Med. 2015 Oct 22;7:107. doi: 10.1186/s13073-015-0234-3.
Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome - the core splicing machinery - that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors.
RNA剪接改变在人类肿瘤中很常见。最近两项关于淋巴瘤和乳腺癌的研究已经确定了剪接体（核心剪接机制）的组成部分，这些组成部分对于由转录因子MYC驱动的恶性转化至关重要。这些发现直接将MYC与RNA剪接失调联系起来，并提出了在MYC驱动的肿瘤中靶向剪接体成分的令人兴奋的可能性。
