El Zomor Hossam, Nour Radwa, Alieldin Adel, Taha Hala, Montasr Mohamed M, Moussa Emad, El Nadi Enas, Ezzat Sameera, Alfaar Ahmad S
Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Egyptian National Cancer Institute, Cairo University, Cairo, Egypt.
Children's Cancer Hospital Egypt, 57357 Cairo, Egypt.
J Egypt Natl Canc Inst. 2015 Dec;27(4):195-203. doi: 10.1016/j.jnci.2015.09.002. Epub 2015 Oct 17.
To study the presenting signs of Retinoblastoma in Egypt at Egypt's main pediatric oncology referral center.
This is a prospective descriptive study (hospital-based registry) conducted at Children's Cancer Hospital Egypt between July 2007 and December 2012.
Out of 262 patients diagnosed with retinoblastoma, 244 were suffering from intra-ocular disease at presentation. One hundred thirty-nine (57%) patients presented with unilateral disease, while 105 (43%) suffered bilateral disease. The mean age at presentation was 20.6 ± 17 months, averaging 18.87 ± 11.76 months for bilateral and 25.72 ± 18.78 months for unilateral disease. The most common clinical presentation was leukocoria in 180 (73.8%) patients, strabismus in 32 (13.1%) patients and decreased visual acuity in 12 (4.9%) patients. Group D and E disease represented 62% of all affected eyes. Patients with advanced disease (Group C-E) had longer duration of symptoms.
In Egypt, retinoblastoma patients present more frequently with advanced disease. There is an ever-increasing need to develop a national team dedicated to studying disease significance and formulating a national awareness program.
在埃及主要的儿科肿瘤转诊中心研究视网膜母细胞瘤的临床表现。
这是一项前瞻性描述性研究（基于医院的登记），于2007年7月至2012年12月在埃及儿童癌症医院进行。
在262例被诊断为视网膜母细胞瘤的患者中，244例在就诊时患有眼内疾病。139例（57%）患者表现为单侧疾病，而105例（43%）患有双侧疾病。就诊时的平均年龄为20.6±17个月，双侧疾病患者平均为18.87±11.76个月，单侧疾病患者平均为25.72±18.78个月。最常见的临床表现是180例（73.8%）患者出现白瞳症，32例（13.1%）患者出现斜视，12例（4.9%）患者视力下降。D组和E组疾病占所有患眼的62%。晚期疾病（C - E组）患者的症状持续时间更长。
在埃及，视网膜母细胞瘤患者更常表现为晚期疾病。越来越需要组建一个专门研究疾病意义并制定全国性宣传计划的国家队。
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