[儿科医生识别视网膜母细胞瘤现有体征和症状的能力]
[The Pediatrician's ability to recognize the presenting signs and symptoms of retinoblastoma].
作者信息
Antoneli Célia B Gianotti, Steinhorst Flávio, Ribeiro Karina de Cássia Braga, Chojniak Martha M M, Novaes Paulo Eduardo R S, Arias Victor, Bianchi Alois
机构信息
Centro de Tratamento e Pesquisa, Hospital do Câncer AC Camargo, São Paulo, SP.
出版信息
Rev Assoc Med Bras (1992). 2004 Oct-Dec;50(4):400-2. doi: 10.1590/s0104-42302004000400030. Epub 2005 Jan 14.
BACKGROUND
Retinoblastoma is the most frequent primary intraocular tumor in children. The most common presenting sign is leukocoria and the second one is strabism. In the developing countries extra ocular disease is seen more frequently because of delayed referral.
METHODS
Two hundred and thirty-nine patients with retinoblastoma admitted at the Pediatrics and Ophthalmology Departments of the Hospital do Cancer AC Camargo from 1986 to 1995 were evaluated regarding lag-time and tumor extension.
RESULTS
Patients referred within less than 6 months presented a higher rate of intraocular disease compared with patients having a lag-time greater than 6 months (75% vs. 25%, p<0.001). No statistically significant difference was noted for patients with extra-ocular tumors.
CONCLUSION
Early diagnosis is the gold standard for patients with Retinoblastoma and the pediatrician's ability to recognize the presenting signs and symptoms can lead to early diagnosis and efficient treatment.
背景
视网膜母细胞瘤是儿童最常见的原发性眼内肿瘤。最常见的临床表现是白瞳症，其次是斜视。在发展中国家，由于转诊延迟，眼外疾病更为常见。
方法
对1986年至1995年在坎马戈癌症医院儿科和眼科住院的239例视网膜母细胞瘤患者的延迟时间和肿瘤扩展情况进行评估。
结果
与延迟时间超过6个月的患者相比，延迟时间少于6个月转诊的患者眼内疾病发生率更高（75%对25%，p<0.001）。眼外肿瘤患者未发现统计学上的显著差异。
结论
早期诊断是视网膜母细胞瘤患者的金标准，儿科医生识别临床表现和症状的能力可导致早期诊断和有效治疗。
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