卡托普利可相互调控肾脏和大脑中的肾素表达。

Renin expression in the kidney and brain is reciprocally controlled by captopril.

作者信息

Tada M, Fukamizu A, Seo M S, Takahashi S, Murakami K

机构信息

Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.

出版信息

Biochem Biophys Res Commun. 1989 Mar 31;159(3):1065-71. doi: 10.1016/0006-291x(89)92217-1.

DOI:10.1016/0006-291x(89)92217-1

PMID:2649097

Abstract

The tissue distribution of rat renin mRNA was examined. Sensitive RNase protection analyses demonstrated that renin mRNA are produced by the extra-renal tissues such as adrenal, brain, liver, lung, pituitary and testis. In response to sodium depletion and captopril treatment, the expression of mRNAs encoding rat renin were in a tissue-specific manner. The level of kidney renin mRNA remarkably increased in sodium-depleted rats treated with captopril, whereas that of brain renin mRNA definitely decreased. No significant change in the level of liver renin mRNA was observed after the same treatment. These results suggest that the expression of cerebral renin is regulated by physiological stimuli independent of its extra-cerebral expression.

摘要

研究了大鼠肾素mRNA的组织分布。灵敏的核糖核酸酶保护分析表明，肾素mRNA由肾上腺、脑、肝、肺、垂体和睾丸等肾外组织产生。对钠耗竭和卡托普利治疗的反应中，编码大鼠肾素的mRNA表达呈组织特异性方式。在用卡托普利治疗的钠耗竭大鼠中，肾脏肾素mRNA水平显著增加，而脑肾素mRNA水平则明显降低。相同处理后，肝脏肾素mRNA水平未观察到显著变化。这些结果表明，脑肾素的表达受生理刺激调节，独立于其脑外表达。