人类α-珠蛋白基因簇的分子遗传学综述。 - Suppr

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超能文献

A review of the molecular genetics of the human alpha-globin gene cluster.

作者信息

Higgs D R, Vickers M A, Wilkie A O, Pretorius I M, Jarman A P, Weatherall D J

机构信息

Nuffield Department of Clinical Medicine, John Radcliff Hospital, Oxford, England.

出版信息

Blood. 1989 Apr;73(5):1081-104.

PMID:2649166

Abstract

摘要

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A review of the molecular genetics of the human alpha-globin gene cluster.人类α-珠蛋白基因簇的分子遗传学综述。

Blood. 1989 Apr;73(5):1081-104.

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Alpha alpha alpha alpha anti-3.7 type II: a new alpha-globin gene rearrangement suggesting that the alpha-globin gene duplication could be caused by intrachromosomal recombination.αααα抗3.7 II型：一种新的α珠蛋白基因重排，提示α珠蛋白基因重复可能由染色体内重组引起。

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The alpha-thalassemias.α地中海贫血

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Haematological phenotypes in a family with triplicated alpha-globin gene, beta zero 39 and delta+27 thalassaemia mutations.一个具有α-珠蛋白基因三倍体、β⁰39和δ+27地中海贫血突变的家族中的血液学表型。

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Human alpha-globin gene expression is silenced by terminal truncation of chromosome 16p beginning immediately 3' of the zeta-globin gene.人类α-珠蛋白基因的表达因16号染色体短臂从ζ-珠蛋白基因3'端紧邻处开始的末端截短而沉默。

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Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster.由人类α珠蛋白基因簇上游一个大的（62 kb）缺失引起的α地中海贫血。

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