分子成像引导下的介入性热疗在乳腺癌治疗中的应用

Molecular Imaging-Guided Interventional Hyperthermia in Treatment of Breast Cancer.

作者信息

Zhou Yurong, Sun Jihong, Yang Xiaoming

机构信息

Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, Zhejiang 310016, China.

Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, Zhejiang 310016, China ; Image-Guided Bio-Molecular Interventions Research, Department of Radiology, University of Washington School of Medicine, 815 Mercer Street, Room S470, Seattle, WA 98109, USA.

出版信息

Biomed Res Int. 2015;2015:505269. doi: 10.1155/2015/505269. Epub 2015 Sep 30.

DOI:10.1155/2015/505269

PMID:26491673

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4605349/

Abstract

Breast cancer is the most frequent malignancy in women worldwide. Although it is commonly treated via chemotherapy, responses vary among its subtypes, some of which are relatively insensitive to chemotherapeutic drugs. Recent studies have shown that hyperthermia can enhance the effects of chemotherapy in patients with refractory breast cancer or without surgical indications. Recent advances in molecular imaging may not only improve early diagnosis but may also facilitate the development and response assessment of targeted therapies. Combining advanced techniques such as molecular imaging and hyperthermia-integrated chemotherapy should open new avenues for effective management of breast cancer.

摘要

乳腺癌是全球女性中最常见的恶性肿瘤。尽管通常通过化疗进行治疗，但其各亚型的反应有所不同，其中一些对化疗药物相对不敏感。最近的研究表明，热疗可以增强难治性乳腺癌或无手术指征患者的化疗效果。分子成像的最新进展不仅可以改善早期诊断，还可以促进靶向治疗的开发和疗效评估。将分子成像和热疗联合化疗等先进技术相结合，应为乳腺癌的有效管理开辟新途径。