新生儿重症监护病房中早产儿葡萄糖-6-磷酸脱氢酶筛查项目的评估

Assessment of G6PD screening program in premature infants in a NICU.

作者信息

Lam R, Li H, Nock M L

机构信息

Division of Neonatology, Department of Pediatrics, Oregon Health and Science University, Doernbecher Children's Hospital, Portland, OR, USA.

Center for Clinical Investigation, Case Western Reserve University, Cleveland, OH, USA.

出版信息

J Perinatol. 2015 Dec;35(12):1027-9. doi: 10.1038/jp.2015.129. Epub 2015 Oct 22.

DOI:10.1038/jp.2015.129

PMID:26491849

Abstract

OBJECTIVE

Targeted screening for glucose-6-phosphate dehydrogenase deficiency (G6PDdef) using fluorescent spot test (FST) is done in our newborn nursery (NN) and now in our NICU. Premature infants have higher G6PD levels than term infants. FST may result in under diagnosis of G6PDdef in preterms. We sought to determine if FST is appropriate for diagnosis of G6PDdef at<35 weeks and assess screening in NICU.

STUDY DESIGN

Retrospective chart review of male, inborn infants<35 weeks in NICU from 2008 to 2011. Difference in G6PDdef incidence<5% between NN and NICU was acceptable for equivalence.

RESULTS

Out of 679 subjects, 442 were screened for G6PDdef and 11.3% had abnormal results. Binomial testing comparing 11.3% (95% confidence interval (CI) 8.5 to 14.6) incidence of G6PDdef in NICU and reported incidence in NN (11%) demonstrated no difference. 12.2% of Black/African American males were not screened.

CONCLUSION

FST is appropriate for screening all at-risk newborns. A number of at-risk premature males were not screened.

摘要

目的

在我们的新生儿病房（NN）以及现在的新生儿重症监护病房（NICU），采用荧光斑点试验（FST）对葡萄糖-6-磷酸脱氢酶缺乏症（G6PDdef）进行靶向筛查。早产儿的G6PD水平高于足月儿。FST可能导致早产儿G6PDdef诊断不足。我们试图确定FST是否适用于诊断孕周<35周的G6PDdef，并评估NICU中的筛查情况。