Robison L L, Buckley J D, Daigle A E, Wells R, Benjamin D, Arthur D C, Hammond G D
Department of Pediatrics, University of Minnesota Health Sciences Center, Minneapolis.
Cancer. 1989 May 15;63(10):1904-11.
The Childrens Cancer Study Group conducted a case-control study designed to assess in utero and postnatal exposures in children with acute nonlymphoblastic leukemia (ANLL). Analyses were performed for reported maternal use of medications and drugs in the year preceding and during the index pregnancy of the 204 case-control pairs. An 11-fold risk (P = 0.003) was found for maternal use of mind-altering drugs just prior to or during the index pregnancy. Compared with ANLL cases not exposed to marijuana, exposed cases were significantly younger at diagnosis of ANLL (P less than 0.01) and were more often of the myelomonocytic and monocytic subtypes (P less than 0.01). Use of antinausea medication for more than 11 weeks was also associated with a significantly elevated relative risk of 2.81 and a dose-response relationship was noted (P = 0.05 for trend). These results suggest that maternal drug use of marijuana may have an etiologic role in childhood ANLL and may be specific for morphologically defined subgroups.
儿童癌症研究组开展了一项病例对照研究，旨在评估急性非淋巴细胞白血病（ANLL）患儿的宫内及出生后暴露情况。对204对病例对照中报告的母亲在索引妊娠前一年及妊娠期间使用药物和毒品的情况进行了分析。发现母亲在索引妊娠前或妊娠期间使用精神改变药物会使风险增加11倍（P = 0.003）。与未接触大麻的ANLL病例相比，接触大麻的病例在ANLL诊断时明显更年幼（P < 0.01），且更常为髓单核细胞和单核细胞亚型（P < 0.01）。使用抗恶心药物超过11周也与相对风险显著升高2.81相关，且观察到剂量反应关系（趋势P = 0.05）。这些结果表明，母亲使用大麻可能在儿童ANLL中具有病因学作用，且可能对形态学定义的亚组具有特异性。
