de Sousa M
Abel Salazar Institute for the Biomedical Sciences, University of Oporto, Portugal.
Clin Exp Immunol. 1989 Jan;75(1):1-6.
A number of studies done in the last 10 years demonstrate the importance of iron in regulating the expression of T lymphoid cell surface markers, in influencing the expansion of different T cell subsets and in affecting different immune cell functions in vitro. It has been argued that some of the results obtained could be explained by the formation of iron polymers in the experimental conditions used in vitro (Soyano Fernandez & Romano, 1985). In this review the results of studies of immunological function in clinical situations of iron overload are analysed. From this analysis, it is concluded that the majority of the observations made in vitro have a counterpart in vivo, thus providing additional compelling evidence for the importance of iron as an immunoregulator.
过去10年进行的多项研究表明，铁在调节T淋巴细胞表面标志物的表达、影响不同T细胞亚群的扩增以及在体外影响不同免疫细胞功能方面具有重要作用。有人认为，在体外实验条件下获得的一些结果可能是由铁聚合物的形成所解释的（索亚诺·费尔南德斯和罗曼诺，1985年）。在这篇综述中，分析了铁过载临床情况下免疫功能研究的结果。从这一分析得出的结论是，体外观察到的大多数情况在体内都有对应情况，从而为铁作为免疫调节剂的重要性提供了额外的有力证据。
