铁过载中的免疫细胞功能。
Immune cell functions in iron overload.
作者信息
de Sousa M
机构信息
Abel Salazar Institute for the Biomedical Sciences, University of Oporto, Portugal.
出版信息
Clin Exp Immunol. 1989 Jan;75(1):1-6.
Abstract
A number of studies done in the last 10 years demonstrate the importance of iron in regulating the expression of T lymphoid cell surface markers, in influencing the expansion of different T cell subsets and in affecting different immune cell functions in vitro. It has been argued that some of the results obtained could be explained by the formation of iron polymers in the experimental conditions used in vitro (Soyano Fernandez & Romano, 1985). In this review the results of studies of immunological function in clinical situations of iron overload are analysed. From this analysis, it is concluded that the majority of the observations made in vitro have a counterpart in vivo, thus providing additional compelling evidence for the importance of iron as an immunoregulator.
摘要
过去10年进行的多项研究表明，铁在调节T淋巴细胞表面标志物的表达、影响不同T细胞亚群的扩增以及在体外影响不同免疫细胞功能方面具有重要作用。有人认为，在体外实验条件下获得的一些结果可能是由铁聚合物的形成所解释的（索亚诺·费尔南德斯和罗曼诺，1985年）。在这篇综述中，分析了铁过载临床情况下免疫功能研究的结果。从这一分析得出的结论是，体外观察到的大多数情况在体内都有对应情况，从而为铁作为免疫调节剂的重要性提供了额外的有力证据。
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本文引用的文献
1
A non-transferrin-bound serum iron in idiopathic hemochromatosis.特发性血色素沉着症中的非转铁蛋白结合血清铁
Dig Dis Sci. 1980 May;25(5):340-6. doi: 10.1007/BF01308057.
2
Iron uptake and ferritin synthesis by peripheral blood leucocytes in patients with primary idiopathic haemochromatosis.原发性特发性血色素沉着症患者外周血白细胞对铁的摄取及铁蛋白合成
Br J Haematol. 1981 Dec;49(4):649-52. doi: 10.1111/j.1365-2141.1981.tb07276.x.
3
Ferritin synthesis in peripheral blood monocytes in idiopathic hemochromatosis.特发性血色素沉着症患者外周血单核细胞中的铁蛋白合成
J Lab Clin Med. 1982 Jul;100(1):137-45.
4
Hemochromatosis: 1980 update.血色素沉着症：1980年最新情况
Gastroenterology. 1980 Feb;78(2):374-81.
5
Impaired T-cell mitogen responses in some patients with thalassemia intermedia.部分中间型地中海贫血患者的T细胞有丝分裂原反应受损。
Thymus. 1981 Aug;3(2):119-28.
6
Lymphoid cell sets and serum immunoglobulins in patients with thalassaemia intermedia: relationship to serum iron and splenectomy.中间型地中海贫血患者的淋巴细胞集落和血清免疫球蛋白：与血清铁及脾切除术的关系
Br J Haematol. 1980 Jul;45(3):405-16. doi: 10.1111/j.1365-2141.1980.tb07161.x.
7
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Br Med J (Clin Res Ed). 1982 Feb 20;284(6315):542-4. doi: 10.1136/bmj.284.6315.542.
8
Functional defects in phagocytic cells from patients with iron overload.铁过载患者吞噬细胞的功能缺陷。
J Infect. 1984 May;8(3):232-40. doi: 10.1016/s0163-4453(84)93955-0.
9
Thermostable erythrocyte rosette-forming lymphocytes in hereditary hemochromatosis. I. Identification in peripheral blood.遗传性血色素沉着症中的耐热性红细胞花环形成淋巴细胞。I. 外周血中的鉴定
J Clin Immunol. 1984 Mar;4(2):134-42. doi: 10.1007/BF00915047.
10
Monocyte transferrin-iron uptake in hereditary hemochromatosis.遗传性血色素沉着症中单核细胞转铁蛋白-铁摄取情况
Am J Hematol. 1984 May;16(4):347-54. doi: 10.1002/ajh.2830160405.
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