铁过载中的免疫细胞功能。
Immune cell functions in iron overload.
作者信息
de Sousa M
机构信息
Abel Salazar Institute for the Biomedical Sciences, University of Oporto, Portugal.
出版信息
Clin Exp Immunol. 1989 Jan;75(1):1-6.
Abstract
A number of studies done in the last 10 years demonstrate the importance of iron in regulating the expression of T lymphoid cell surface markers, in influencing the expansion of different T cell subsets and in affecting different immune cell functions in vitro. It has been argued that some of the results obtained could be explained by the formation of iron polymers in the experimental conditions used in vitro (Soyano Fernandez & Romano, 1985). In this review the results of studies of immunological function in clinical situations of iron overload are analysed. From this analysis, it is concluded that the majority of the observations made in vitro have a counterpart in vivo, thus providing additional compelling evidence for the importance of iron as an immunoregulator.
摘要
过去10年进行的多项研究表明，铁在调节T淋巴细胞表面标志物的表达、影响不同T细胞亚群的扩增以及在体外影响不同免疫细胞功能方面具有重要作用。有人认为，在体外实验条件下获得的一些结果可能是由铁聚合物的形成所解释的（索亚诺·费尔南德斯和罗曼诺，1985年）。在这篇综述中，分析了铁过载临床情况下免疫功能研究的结果。从这一分析得出的结论是，体外观察到的大多数情况在体内都有对应情况，从而为铁作为免疫调节剂的重要性提供了额外的有力证据。
相似文献
1
Immune cell functions in iron overload.
Clin Exp Immunol. 1989 Jan;75(1):1-6.
2
Effects of iron overload on the immune system.
Ann Clin Lab Sci. 2000 Oct;30(4):354-65.
3
Relative impact of HLA phenotype and CD4-CD8 ratios on the clinical expression of hemochromatosis.
Hepatology. 1997 Feb;25(2):397-402. doi: 10.1002/hep.510250223.
4
The CD8+ T-lymphocyte profile as a modifier of iron overload in HFE hemochromatosis: an update of clinical and immunological data from 70 C282Y homozygous subjects.
Blood Cells Mol Dis. 2006 Jul-Aug;37(1):33-9. doi: 10.1016/j.bcmd.2006.04.004. Epub 2006 Jun 9.
5
Lymphocyte subsets and specific T-cell immune response in thalassemia.
Cytometry. 2000 Feb 15;42(1):11-7.
6
Iron-related disturbances of cell-mediated immunity in multitransfused children with thalassemia major.
Clin Exp Immunol. 1987 Apr;68(1):138-45.
7
Molecular analysis of iron overload in beta2-microglobulin-deficient mice.
Blood Cells Mol Dis. 2004 Sep-Oct;33(2):125-31. doi: 10.1016/j.bcmd.2004.05.003.
8
T lymphocytes and iron overload: novel correlations of possible significance to the biology of the immunological system.
Mem Inst Oswaldo Cruz. 1992;87 Suppl 5:23-9. doi: 10.1590/s0074-02761992000900003.
9
Hepatic iron concentration, fibrosis and response to venesection associated with the A77D and V162del "loss of function" mutations in ferroportin disease.
Blood Cells Mol Dis. 2008 May-Jun;40(3):328-33. doi: 10.1016/j.bcmd.2007.11.001. Epub 2007 Dec 21.
10
Can iron chelators influence the progression of atherosclerosis?
Hemoglobin. 2008;32(1-2):123-34. doi: 10.1080/03630260701726871.
引用本文的文献
1
Causality effect of 21 metals in plasma and serum, 731 immunocytes, and schizophrenia: an intermediary Mendelian randomization study in East Asian populations.
Compr Psychoneuroendocrinol. 2025 Jun 3;23:100304. doi: 10.1016/j.cpnec.2025.100304. eCollection 2025 Aug.
2
Iron and the immune system.
Nat Rev Immunol. 2025 Jun 16. doi: 10.1038/s41577-025-01193-y.
3
Evading Doxorubicin-Induced Systemic Immunosuppression Using Ultrasound-Responsive Liposomes Combined with Focused Ultrasound.
Pharmaceutics. 2022 Nov 25;14(12):2603. doi: 10.3390/pharmaceutics14122603.
4
PCBP1 is associated with rheumatoid arthritis by affecting RNA products of genes involved in immune response in Th1 cells.
Sci Rep. 2022 May 19;12(1):8398. doi: 10.1038/s41598-022-12594-7.
5
Post-mortem liver and bone marrow iron quantification in haemodialysis patients: A prospective cohort study.
EBioMedicine. 2022 Mar;77:103921. doi: 10.1016/j.ebiom.2022.103921. Epub 2022 Mar 8.
6
The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis.
Theranostics. 2021 Sep 13;11(19):9503-9518. doi: 10.7150/thno.63992. eCollection 2021.
7
The Iron Curtain: Macrophages at the Interface of Systemic and Microenvironmental Iron Metabolism and Immune Response in Cancer.
Front Immunol. 2021 Apr 27;12:614294. doi: 10.3389/fimmu.2021.614294. eCollection 2021.
8
Chimeric Protein IPath with Chelating Activity Improves Atlantic Salmon's Immunity against Infectious Diseases.
Vaccines (Basel). 2021 Apr 9;9(4):361. doi: 10.3390/vaccines9040361.
9
Clinical Outcomes of Radical Surgery and Antimicrobial Agents in Vascular Pythiosis: A Multicenter Prospective Study.
J Fungi (Basel). 2021 Feb 4;7(2):114. doi: 10.3390/jof7020114.
10
Iron Administration, Infection, and Anemia Management in CKD: Untangling the Effects of Intravenous Iron Therapy on Immunity and Infection Risk.
Kidney Med. 2020 Mar 27;2(3):341-353. doi: 10.1016/j.xkme.2020.01.006. eCollection 2020 May-Jun.
本文引用的文献
1
A non-transferrin-bound serum iron in idiopathic hemochromatosis.
Dig Dis Sci. 1980 May;25(5):340-6. doi: 10.1007/BF01308057.
2
Iron uptake and ferritin synthesis by peripheral blood leucocytes in patients with primary idiopathic haemochromatosis.
Br J Haematol. 1981 Dec;49(4):649-52. doi: 10.1111/j.1365-2141.1981.tb07276.x.
3
Ferritin synthesis in peripheral blood monocytes in idiopathic hemochromatosis.
J Lab Clin Med. 1982 Jul;100(1):137-45.
4
Hemochromatosis: 1980 update.
Gastroenterology. 1980 Feb;78(2):374-81.
5
Impaired T-cell mitogen responses in some patients with thalassemia intermedia.
Thymus. 1981 Aug;3(2):119-28.
6
Lymphoid cell sets and serum immunoglobulins in patients with thalassaemia intermedia: relationship to serum iron and splenectomy.
Br J Haematol. 1980 Jul;45(3):405-16. doi: 10.1111/j.1365-2141.1980.tb07161.x.
7
Listeria monocytogenes meningitis and decreased phagocytosis associated with iron overload.
Br Med J (Clin Res Ed). 1982 Feb 20;284(6315):542-4. doi: 10.1136/bmj.284.6315.542.
8
Functional defects in phagocytic cells from patients with iron overload.
J Infect. 1984 May;8(3):232-40. doi: 10.1016/s0163-4453(84)93955-0.
9
Thermostable erythrocyte rosette-forming lymphocytes in hereditary hemochromatosis. I. Identification in peripheral blood.
J Clin Immunol. 1984 Mar;4(2):134-42. doi: 10.1007/BF00915047.
10
Monocyte transferrin-iron uptake in hereditary hemochromatosis.
Am J Hematol. 1984 May;16(4):347-54. doi: 10.1002/ajh.2830160405.
Zotero 插件