单核细胞增生李斯特菌脑膜炎与铁过载相关的吞噬作用降低。
Listeria monocytogenes meningitis and decreased phagocytosis associated with iron overload.
作者信息
van Asbeck B S, Verbrugh H A, van Oost B A, Marx J J, Imhof H W, Verhoef J
出版信息
Br Med J (Clin Res Ed). 1982 Feb 20;284(6315):542-4. doi: 10.1136/bmj.284.6315.542.
Abstract
A patient with Listeria monocytogenes meningitis was found to have idiopathic haemochromatosis and monocytes with reduced phagocytic capacity. The phagocytic function recovered completely after a series of therapeutic phlebotomies. In-vitro iron had a deleterious effect on the phagocytic capacity of monocytes and granulocytes. These findings show that iron overload in the host can increase susceptibility to L monocytogenes infection not only by increasing the virulence of the organism but also by reducing the phagocytic capacity of the monocytes.
摘要
一名患有单核细胞增生李斯特菌脑膜炎的患者被发现患有特发性血色素沉着症，其单核细胞吞噬能力降低。经过一系列治疗性放血后，吞噬功能完全恢复。体外铁对单核细胞和粒细胞的吞噬能力有有害影响。这些发现表明，宿主中的铁过载不仅可通过增加病原体的毒力，还可通过降低单核细胞的吞噬能力来增加对单核细胞增生李斯特菌感染的易感性。
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