Department of Neurology, Washington University, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA; The Knight Alzheimer's Disease Research Center, Washington University, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA.
Department of Neurology, Washington University, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA; The Knight Alzheimer's Disease Research Center, Washington University, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA.
Neuron. 2015 Oct 21;88(2):237-9. doi: 10.1016/j.neuron.2015.10.008.
Blood-brain barrier disruption is believed to occur in Alzheimer's disease, which could influence the bioavailability of drugs within the brain. However, in this issue of Neuron, Bien-Ly et al. (2015) report no evidence of widespread blood-brain barrier dysfunction.
据信，血脑屏障破坏发生在阿尔茨海默病中，这可能会影响大脑内药物的生物利用度。然而，Bien-Ly 等人（2015）在本期《神经元》杂志中报告称，没有广泛的血脑屏障功能障碍的证据。
