Moradi Ali Mohammad, Aj Omid, Paydar Shahram, Ketabchi Farzaneh, Sheid Moosavi Seyed Mostafa, Bolandparvaz Shahram, Abassi Hamid Reza, Tamadon Aryan Dokht, Mehrabani Davood
Department of Surgery, Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Emerg (Tehran). 2015 Fall;3(4):150-4.
The effect of severe soft tissue injury on the severity of hemorrhagic shock is still unknown. Therefore, the present study was aimed to determine hemodynamic and metabolic changes in traumatic/hemorrhagic shock in an animal model.
Forty male rats were randomly divided into 4 equal groups including sham, hemorrhagic shock, soft tissue injury, and hemorrhagic shock + soft tissue injury groups. The changes in blood pressure, central venous pressure (CVP) level, acidity (pH), and base excess were dynamically monitored and comparedsented.
Mean arterial blood pressure decreased significantly in hemorrhagic shock (df: 12; F=10.9; p<0.001) and severe soft tissue injury + hemorrhagic shock (df: 12; F=11.7; p<0.001) groups 15 minutes and 5 minutes after injury, respectively. A similar trend was observed in CVP in severe soft tissue injury + hemorrhagic shock group (df: 12; F=8.9; p<0.001). After 40 minutes, pH was significantly lower in hemorrhagic shock (df: 12; F=6.8; p=0.009) and severe soft tissue injury + hemorrhagic shock (df: 12; F=7.9; p=0.003) groups. Base excess changes during follow ups have a similar trend. (df: 12; F=11.3; p<0.001).
The results of this study have shown that the effect of hemorrhage on the decrease of mean arterial blood pressure, CVP, pH, and base excess is the same in the presence or absence of soft tissue injury.
严重软组织损伤对失血性休克严重程度的影响尚不清楚。因此，本研究旨在确定动物模型中创伤性/失血性休克时的血流动力学和代谢变化。
40只雄性大鼠随机分为4组，每组10只，分别为假手术组、失血性休克组、软组织损伤组和失血性休克+软组织损伤组。动态监测并比较血压、中心静脉压（CVP）水平、酸碱度（pH）和碱剩余的变化。
失血性休克组（自由度：12；F=10.9；p<0.001）和严重软组织损伤+失血性休克组（自由度：12；F=11.7；p<0.001）分别在损伤后15分钟和5分钟时平均动脉血压显著下降。严重软组织损伤+失血性休克组的CVP也有类似趋势（自由度：12；F=8.9；p<0.001）。40分钟后，失血性休克组（自由度：12；F=6.8；p=0.009）和严重软组织损伤+失血性休克组（自由度：12；F=7.9；p=0.003）的pH显著降低。随访期间碱剩余变化有类似趋势（自由度：12；F=11.3；p<0.001）。
本研究结果表明，无论有无软组织损伤，出血对平均动脉血压、CVP、pH和碱剩余降低的影响是相同的。
