Wang Na, Zhou Ying, Fu Chaowei, Wang Hexing, Huang Peixin, Wang Bin, Su Meifang, Jiang Feng, Fang Hong, Zhao Qi, Chen Yue, Jiang Qingwu
Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Department of Chronic Disease Control and Prevention, Haimen City Center for Disease Control and Prevention, Haimen, China.
PLoS One. 2015 Oct 23;10(10):e0141248. doi: 10.1371/journal.pone.0141248. eCollection 2015.
Although several studies have evaluated the relationship between bisphenol A (BPA) and thyroid functions, their results are not entirely consistent. Little is known about BPA in relation to thyroid volume and structure.
We examined the association of BPA with thyroid volume and thyroid nodules using data from 718 Chinese children living in the East Coast of China in 2012. First morning urine samples were collected for the determination of urinary BPA, creatinine, and urinary iodine concentrations (UIC). Thyroid volume (TV) and nodules were assessed by thyroid ultrasonography.
The median of TV was 3.14ml. 459(63.9%) children took iodized salt at home and the median of UIC was 159μg/l. BPA was detected in 99.9% of the urine samples and the medians for boys and girls were 2.64 and 2.35μg/g creatinine, respectively. Of all participants 14.0% had thyroid nodules. Urinary BPA concentration was inversely associated with thyroid volume (β = -0.033, 95% CI: -0.053, -0.013) and the risk for multiple nodules (OR = 0.78; 95% CI: 0.63, 0.97). The associations above were similar for children who consumed iodized salt and those consumed non-iodized salt.
The data suggest that BPA may be one of the influencing factors for TV and thyroid nodules and its effects are independent of iodine nutrition status in children.
尽管多项研究评估了双酚A（BPA）与甲状腺功能之间的关系，但其结果并不完全一致。关于BPA与甲状腺体积和结构的关系知之甚少。
我们利用2012年居住在中国东海岸的718名中国儿童的数据，研究了BPA与甲状腺体积和甲状腺结节的关联。收集首次晨尿样本以测定尿BPA、肌酐和尿碘浓度（UIC）。通过甲状腺超声评估甲状腺体积（TV）和结节。
TV的中位数为3.14ml。459名（63.9%）儿童在家中食用加碘盐，UIC的中位数为159μg/l。99.9%的尿样中检测到BPA，男孩和女孩的中位数分别为2.64和2.35μg/g肌酐。所有参与者中14.0%有甲状腺结节。尿BPA浓度与甲状腺体积呈负相关（β=-0.033，95%CI：-0.053，-0.013），与多发结节的风险呈负相关（OR=0.78；95%CI：0.63，0.97）。食用加碘盐的儿童和食用非加碘盐的儿童上述关联相似。
数据表明，BPA可能是影响儿童甲状腺体积和甲状腺结节的因素之一，其作用独立于儿童的碘营养状况。
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