双酚 A 对新生儿和儿童甲状腺功能的影响：文献系统评价。
The Impact of Bisphenol A on Thyroid Function in Neonates and Children: A Systematic Review of the Literature.
机构信息
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
出版信息
Nutrients. 2021 Dec 30;14(1):168. doi: 10.3390/nu14010168.
BACKGROUND
Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in plastic products that may have an adverse effect on several physiologic functions in children. The aim of this systematic review is to summarize the current knowledge of the impact of BPA concentrations on thyroid function in neonates, children, and adolescents.
METHODS
A systematic search of Medline, Scopus, Clinical Trials.gov, Cochrane Central Register of Controlled Trials CENTRAL, and Google Scholar databases according to PRISMA guidelines was performed. Only case-control, cross-sectional, and cohort studies that assessed the relationship between Bisphenol A and thyroid function in neonates and children aged <18 years were included. Initially, 102 articles were assessed, which were restricted to 73 articles after exclusion of duplicates. A total of 73 articles were assessed by two independent researchers based on the title/abstract and the predetermined inclusion and exclusion criteria. According to the eligibility criteria, 18 full-text articles were selected for further assessment. Finally, 12 full-text articles were included in the present systematic review.
RESULTS
The presented studies offer data that suggest a negative correlation of BPA concentrations with TSH in children, a gender-specific manner of action, and a potential effect on proper neurodevelopment. However, the results are inconclusive with respect to specific thyroid hormone concentrations and the effect on thyroid autoimmunity.
CONCLUSION
The potential negative effect of BPA in the developing thyroid gland of children that may affect proper neurodevelopment, suggesting the need to focus future research on designing studies that elucidate the underlying mechanisms and the effects of BPA in thyroid function in early life.
背景
双酚 A（BPA）是一种广泛应用于塑料制品的内分泌干扰化学物质，可能对儿童的几种生理功能产生不利影响。本系统评价的目的是总结目前关于 BPA 浓度对新生儿、儿童和青少年甲状腺功能影响的知识。
方法
根据 PRISMA 指南，对 Medline、Scopus、ClinicalTrials.gov、Cochrane 中央对照试验注册中心（CENTRAL）和 Google Scholar 数据库进行系统搜索。仅纳入评估双酚 A 与新生儿和<18 岁儿童甲状腺功能之间关系的病例对照、横断面和队列研究。最初评估了 102 篇文章，排除重复后限制为 73 篇。两名独立研究人员根据标题/摘要以及预先确定的纳入和排除标准评估了 73 篇文章。根据纳入标准，选择了 18 篇全文文章进行进一步评估。最后，有 12 篇全文文章被纳入本系统评价。
结果
目前的研究提供的数据表明，BPA 浓度与儿童 TSH 呈负相关，存在性别特异性作用，并且可能对正常神经发育产生影响。然而，关于特定甲状腺激素浓度和对甲状腺自身免疫的影响，结果尚无定论。
结论
BPA 对儿童发育中甲状腺的潜在负面影响可能会影响正常的神经发育，这表明需要关注未来的研究，以阐明潜在机制以及 BPA 对生命早期甲状腺功能的影响。
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