Fathala Ahmed, Alreshoodi Saleh, Rujaib Mashael Al, Shoukri Mohamed, Sergani Hani Al, Buriki Jehad Al, Sugair Abdulaziz Al
Ahmed Fathala MD, Department of Radiology,, King Faisal Specialist Hospital and Research Centre,, MBC 28, Riyadh 11211, Saudi Arabia, T: +966-11-4647272 ext 33812,
Ann Saudi Med. 2015 Jul-Aug;35(4):298-302. doi: 10.5144/0256-4947.2015.298.
Coronary artery calcification (CAC) is indicated by calcium deposits in the coronary artery wall. Calcification is a component of atherosclerosis and coronary artery disease. Currently, there are no data on calcification in Saudi women at high risk of coronary artery disease. The aim of this study was to investigate the prevalence and percentiles of CAC score in high-risk asymptotic women in Saudi Arabia with comparison of age-specific CAC percentiles derived from large population-based published study in the United States.
Retrospective analysis of CAC scores (CACS) at a single tertiary care center.
Between January 2011 and April 2015, women referred for CAC screening because of the presence of one or more CAD risk factors were enrolled in the study. CT scans were interpreted by an experienced radiographic technologist, and confirmed by a radiologist.
The study sample consisted of 918 women, mean (SD) age of 55 (11) years. All patients were asymp.tomatic and referred by their primary care physician or cardiologist for CAC screening because presence of one or more CAD risks factors. CAD risk factors included diabetes, hypertension, hypercholesterolemia, family history of CAD, and obesity. Baseline CAD risk factors were remarkably higher than in the US comparator group. CACS for 25th, 50th, 75th, and 90th percentiles were calculated. The 75th and 90th CACS percentiles in Saudi women were significantly higher than the US percentiles. Age and diabetes are the most independent predictor of severity of CAC.
A potential bias due to sample collection because data was from a single tertiary care center, the study was retrospective and the sample size was small.
There are significantly higher CACS percentiles in Saudi women compared with international data. Application of available published percentiles to a local population is not applicable and underestimates the severity of subclinical atherosclerosis. A large local population-based study is warranted to establish local CACS percentiles for a better understanding CAD screening, diagnosis, and treatment.
冠状动脉钙化（CAC）表现为冠状动脉壁中的钙沉积。钙化是动脉粥样硬化和冠状动脉疾病的一个组成部分。目前，尚无关于沙特患冠状动脉疾病高风险女性钙化情况的数据。本研究的目的是调查沙特高风险无症状女性中CAC评分的患病率和百分位数，并与美国一项基于大规模人群的已发表研究得出的特定年龄CAC百分位数进行比较。
在一家三级医疗中心对CAC评分（CACS）进行回顾性分析。
2011年1月至2015年4月期间，因存在一种或多种CAD危险因素而被转诊进行CAC筛查的女性被纳入研究。CT扫描由经验丰富的放射技师解读，并由放射科医生确认。
研究样本包括918名女性，平均（标准差）年龄为55（11）岁。所有患者均无症状，因存在一种或多种CAD危险因素而由其初级保健医生或心脏病专家转诊进行CAC筛查。CAD危险因素包括糖尿病、高血压、高胆固醇血症、CAD家族史和肥胖。基线CAD危险因素显著高于美国对照组。计算了第25、50、75和90百分位数的CACS。沙特女性的第75和90百分位数CACS显著高于美国的百分位数。年龄和糖尿病是CAC严重程度最独立的预测因素。
由于样本收集存在潜在偏差，因为数据来自单一的三级医疗中心，该研究为回顾性研究且样本量较小。
与国际数据相比，沙特女性的CACS百分位数显著更高。将现有的已发表百分位数应用于当地人群并不适用，且低估了亚临床动脉粥样硬化的严重程度。有必要开展一项基于当地大规模人群的研究，以确定当地的CACS百分位数，以便更好地理解CAD的筛查、诊断和治疗。
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