母亲显性甲状腺功能减退与新生儿神经行为结局：来自印度北部碘缺乏地区的队列研究

Maternal Overt Hypothyroidism and Neurobehavioral Outcome of Neonates: A Cohort Study from an Iodine-deficient Area of Northern India.

作者信息

Ganaie Mohammad Ashraf, Charoo Bashir A, Sofi Riyaz Ahmad, Ahmed Asif, Bhat Javeed Iqbal

机构信息

Department of *Endocrinology, AIIMS, New Delhi; and Department of Pediatrics, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir; India. Correspondence to: Dr Javeed Iqbal Bhat, Department of Pediatrics, SKIMS Soura, Jammu and Kashmir 190 011, India.

出版信息

Indian Pediatr. 2015 Oct;52(10):864-6. doi: 10.1007/s13312-015-0733-8.

DOI:10.1007/s13312-015-0733-8

PMID:26499010

Abstract

OBJECTIVE

To study the relation between maternal overt hypothyroidism and neurodevelopmental outcome of neonates in iodine-deficient region of Northern India (Kashmir Valley).

DESIGN

Prospective cohort study.

SETTING

Endocrinology department of a tertiary-care hospital.

PARTICIPANTS

82 hypothyroid pregnant women were enrolled and followed up till delivery. The neonates born to this group represented the case neonates. 51 euthyroid healthy pregnant women were selected as control group. The neonates born to these mothers served as controls.

MAIN OUTCOME MEASURES

Early neonatal behavioral assessment at 3-4 weeks of age.

RESULTS

The mean TSH and free T4 in neonates of mothers with well controlled hypothyroidism was significantly different from those born to mothers with poorly controlled hypothyroidism and controls in 1st trimester, but the difference was statistically insignificant for 2nd and 3rd trimester values.