Wu H B, Zhong J M, Hu R Y, Wang H, Gong W W, Pan J, Fei F R, Wang M, Guo L H, Yang L, Yu M
Department of NCDs Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Zhejiang Provincial Center for Cardio-cerebrovascular Diseases Control and Prevention, Zhejiang Hospital, Hangzhou, China.
Diabet Med. 2016 Oct;33(10):1339-46. doi: 10.1111/dme.13010. Epub 2015 Nov 22.
To investigate the incidence rates and trends in Type 1 diabetes in children and adolescents aged 0-19 years in the registered Zhejiang population over the period 2007-2013 by age, sex and calendar year.
In total, 611 individuals with newly diagnosed Type 1 diabetes were identified from 30 districts in Zhejiang province over the study period. Annual incidence and 95% confidence intervals (CI) by age group and sex were calculated per 100 000 person-years. Trends in diabetes incidence and the associations of age and sex with Type 1 diabetes were assessed using Poisson regression models.
The mean annual age-standardized incidence of diabetes was 2.02/100 000 person-years (95% CI: 1.92-2.12), with an average annual increase of 12.0% (95% CI: 7.6-16.6%) over the study period. The risk for Type 1 diabetes in girls was estimated to be 1.25 (95% CI: 1.07-1.47) times higher than that in boys. Compared with those aged 0-4 years, the 5-9, 10-14 and 15-19 years age groups were at significantly greater risk, with adjusting incidence rate ratios of 3.54, 6.58 and 5.39, respectively. The mean age at diagnosis decreased significantly from 12.85 years in 2007 to 11.21 years in 2013. A steep rise in diabetes incidence was observed in the under 5 years age group, which showed the greatest increase at 33.61%.
The incidence of diabetes in Zhejiang was relatively low, although rapidly rising trends have been found in recent years, particularly in younger children. Further monitoring and research are urgently required to better understand possible environmental risk factors and formulate preventive strategies.
调查2007 - 2013年期间浙江省登记人口中0 - 19岁儿童及青少年1型糖尿病的发病率及发病趋势，分析其年龄、性别及历年变化情况。
在研究期间，从浙江省30个地区共识别出611例新诊断的1型糖尿病患者。按每10万人年计算各年龄组和性别的年发病率及95%置信区间（CI）。采用泊松回归模型评估糖尿病发病率的趋势以及年龄和性别与1型糖尿病的关联。
糖尿病的年均年龄标准化发病率为2.02/10万人年（95% CI：1.92 - 2.12），在研究期间年均增长12.0%（95% CI：7.6 - 16.6%）。估计女孩患1型糖尿病的风险比男孩高1.25倍（95% CI：1.07 - 1.47）。与0 - 4岁年龄组相比，5 - 9岁、10 - 14岁和15 - 19岁年龄组的风险显著更高，调整后的发病率比值分别为3.54、6.58和5.39。诊断时的平均年龄从2007年的12.85岁显著降至2013年的11.21岁。5岁以下年龄组糖尿病发病率急剧上升，增幅最大，为33.61%。
浙江省糖尿病发病率相对较低，但近年来呈快速上升趋势，尤其是年幼儿童。迫切需要进一步监测和研究，以更好地了解可能的环境危险因素并制定预防策略。
