Sinisgalli Ersilia, Bellini Irene, Indiani Laura, Sala Antonio, Bechini Angela, Bonanni Paolo, Boccalini Sara
Scuola di specializzazione in Igiene e medicina preventiva, Università di Firenze, Italy.
Dip. Scienze della salute, Università di Firenze, Italy.
Epidemiol Prev. 2015 Jul-Aug;39(4 Suppl 1):51-8.
HPV vaccination is recommended in many countries, including Italy, for girls in their twelfth year of age. In some countries, the goal of vaccination coverage has not been reached, and extension to boys has thus been debated.
Aim of this study is to perform a systematic review of pharmaco-economic studies considering the extension of HPV vaccination to boys.
An electronic literature search was performed on Pubmed to identify studies published from 2005 to 2015 in English and Italian. Four search strategies were used, including the terms «HPV», «boys», «vaccination», «economic evaluation», «cost effectiveness», and «epidemiological impact». Screening of titles, abstracts, and full texts was conducted, and economical evaluation of the extension of HPV vaccination to males was considered a criteria of inclusion. A total of 289 articles were identified. Only 15 articles were finally considered pertinent.
The extension of HPV vaccination to boys was cost-effective or potentially cost-effective in 53%and 7%of the studies, respectively. Six studies did not positively evaluate the implementation of this intervention. However, taking into account both the new two-dose vaccination schedule available for all subjects ≤13 years, and the dramatic reduction in the price of vaccines in the last few years, the advantages of universal vaccination are more consistent.
The extension of HPV vaccination to boys is therefore foreseen to become increasingly implemented in the near future.
包括意大利在内的许多国家都建议12岁女孩接种人乳头瘤病毒（HPV）疫苗。在一些国家，疫苗接种覆盖率目标尚未实现，因此将接种范围扩大到男孩的问题引发了讨论。
本研究的目的是对考虑将HPV疫苗接种扩大到男孩的药物经济学研究进行系统综述。
在PubMed上进行电子文献检索，以确定2005年至2015年以英文和意大利文发表的研究。使用了四种检索策略，包括“HPV”“男孩”“疫苗接种”“经济评估”“成本效益”和“流行病学影响”等术语。对标题、摘要和全文进行筛选，将对HPV疫苗接种扩大到男性的经济评估作为纳入标准。共确定了289篇文章。最终仅15篇文章被认为相关。
在53%和7%的研究中，将HPV疫苗接种扩大到男孩分别具有成本效益或潜在成本效益。六项研究对该干预措施的实施没有给予积极评价。然而，考虑到所有13岁及以下人群可用的新的两剂疫苗接种方案，以及过去几年疫苗价格的大幅下降，普遍接种疫苗的优势更加明显。
因此，预计在不久的将来，将HPV疫苗接种扩大到男孩的做法会越来越多地得到实施。
