Gerster J C
Rev Prat. 1989 Mar 2;39(7):569-74.
Destructive arthropathy occurs not only in septic arthritis and inflammatory rheumatism but also in osteo-arthrosis. The destruction may be slowly progressive or conversely very fast. Old age, female sex and local overload are contributing factors. There is no clear-cut evidence that the articular chondrocalcinosis and apatite deposits are associated with destructive arthropathy. Enzymatic release due to the phagocytosis of the microcrystals could be one of the causes of the destruction. There is no clear-cut evidence that the clinical use of intracorticosteroids or of non steroidal anti-inflammatory drugs is reasonable for destructive arthropathy.
破坏性关节病不仅发生于化脓性关节炎和炎性风湿病,也见于骨关节炎。其破坏过程可能进展缓慢,也可能相反,进展非常迅速。老龄、女性及局部负荷过重是促成因素。尚无明确证据表明关节软骨钙质沉着症和磷灰石沉积与破坏性关节病相关。微晶吞噬导致的酶释放可能是破坏的原因之一。尚无明确证据表明皮质类固醇或非甾体类抗炎药用于治疗破坏性关节病具有合理性。