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足月纯母乳喂养新生儿出生后48小时内无症状低血糖的研究

Study of Asymptomatic Hypoglycemia in Full Term Exclusively Breastfed Neonates in First 48 Hours of Life.

作者信息

Samayam Purnima, Ranganathan Pradeep Krishna, Kotari Usha Deepthi, Balasundaram Ravichander

机构信息

Associate Professor, Department of Pediatrics, BGS GIMS , Bangalore, India .

Post Graduate, Department of Pediatrics, MVJMC and RH , Hoskote, India .

出版信息

J Clin Diagn Res. 2015 Sep;9(9):SC07-10. doi: 10.7860/JCDR/2015/14971.6610. Epub 2015 Sep 1.

Abstract

INTRODUCTION

Hypoglycemia is a common metabolic problem in the neonatal period especially in the presence of settings like prematurity, small for gestational age babies and sepsis. Episodes of asymptomatic hypoglycemia may occur in term neonates without apparent risk factors.

AIM

This study was conducted to estimate the incidence of hypoglycemia in healthy, intramural, singleton full term neonates and to correlate the above incidence with maternal factors like parity, mode of delivery and time of initiation of breast feeding after birth.

MATERIALS AND METHODS

A hospital based, prospective longitudinal study involving healthy, term, asymptomatic neonates. Blood glucose values were measured at 1, 6, 24 and 48 hours of life.

RESULTS

The overall incidence of hypoglycemia was 10 % in asymptomatic, healthy term newborns. All the hypoglycemic episodes occurred in the first 24 hours of life. 23.07% of neonates born to primiparous mothers had hypoglycemia, against 5.4% neonates born to multiparous mothers (p<0.05). There was a higher recording of hypoglycemia when breast feeding was initiated > 1 hour after delivery (16.67%) than when breast feeding was initiated within one hour of delivery (7.89%).

CONCLUSION

Asymptomatic hypoglycemia occurred in about 10% of healthy, full term neonates; primiparity and delayed initiation of breast feeding > 1 hour are noted as additional risk factors.

摘要

引言

低血糖是新生儿期常见的代谢问题,尤其是在存在早产、小于胎龄儿和败血症等情况时。无症状低血糖发作可能发生在无明显危险因素的足月儿中。

目的

本研究旨在估计健康的、住院的、单胎足月儿低血糖的发生率,并将上述发生率与母亲因素如产次、分娩方式和出生后开始母乳喂养的时间相关联。

材料与方法

一项基于医院的前瞻性纵向研究,纳入健康、足月、无症状的新生儿。在出生后1、6、24和48小时测量血糖值。

结果

无症状健康足月儿低血糖的总体发生率为10%。所有低血糖发作均发生在出生后的前24小时内。初产妇所生新生儿低血糖发生率为23.07%,经产妇所生新生儿低血糖发生率为5.4%(p<0.05)。分娩后母乳喂养开始时间>1小时的新生儿低血糖发生率(16.67%)高于分娩后1小时内开始母乳喂养的新生儿(7.89%)。

结论

约10%的健康足月儿发生无症状低血糖;初产和母乳喂养开始时间延迟>1小时被视为额外的危险因素。

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