HIV-1 储库与免疫激活的关联。
HIV-1 Reservoir Association with Immune Activation.
机构信息
Laboratory of Immunovirology, Department of Infectious Diseases, Institute Ramón y Cajal of Health Research (IRyCIS), Universitary Hospital Ramón y Cajal, Madrid, Spain.
出版信息
EBioMedicine. 2015 Aug 16;2(9):1020-1. doi: 10.1016/j.ebiom.2015.08.025. eCollection 2015 Sep.
Abstract
In this issue of EBioMedicine, Ruggiero and colleagues describe immune activation biomarkers associated with the size of the HIV reservoir in a carefully designed cross-sectional study. The cohort consists of a homogeneous sample of HIV-1-infected patients with long-term plasma HIV-1 RNA suppression under antiretroviral treatment (ART). It is crucial to explore the potential utility of biomarkers that are easier (less labor intensive, less expensive) to measure than integrated HIV DNA load, in order to quickly and accurately quantify cellular reservoirs of HIV.
摘要
本期《eBioMedicine》中，Ruggiero 等人描述了一项精心设计的横断面研究中与 HIV 储存库大小相关的免疫激活生物标志物。该队列由一组接受抗逆转录病毒治疗（ART）的长期血浆 HIV-1 RNA 抑制的 HIV-1 感染患者组成，具有同质性。探索比整合 HIV DNA 载量更容易（劳动强度更低、成本更低）测量的生物标志物的潜在效用非常重要，以便快速准确地定量 HIV 的细胞储存库。
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