异种移植
Xenografts.
作者信息
Reemtsma K
机构信息
Department of Surgery, Columbia University, College of Physicians and Surgeons, New York, New York 10032-3784.
出版信息
Transplant Proc. 1989 Feb;21(1 Pt 1):517-8.
Increasing success in clinical organ transplantation has had the paradoxical effect of highlighting the problem of donor organ shortage. Even with improved procurement of human organs, there remains a shortage. This factor has provided a continuing stimulation for studies directed toward eventual use of non-human organs in man. Studies done a quarter-century ago showed that chimpanzee kidneys transplanted into patients functioned for as long as nine months. There are serious logistic and ethical problems surrounding the use of this species. We have studied cardiac transplantation in a lower primate model (monkey-baboon), and these studies provide encouragement in the field of xenotransplantation.
临床器官移植成功率的不断提高却产生了自相矛盾的效果，凸显了供体器官短缺的问题。即便人体器官获取情况有所改善，但短缺问题依然存在。这一因素持续推动着旨在最终在人体使用非人类器官的研究。25年前开展的研究表明，移植到患者体内的黑猩猩肾脏能发挥功能长达9个月。使用该物种存在严重的后勤和伦理问题。我们在一种低等灵长类动物模型（猴-狒狒）中研究了心脏移植，这些研究为异种移植领域带来了希望。
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