Bonnet C, Lejeune M, Van Kemseke C, Bron D, Beguin Y
Rev Med Suisse. 2015 Aug 26;11(483):1549-56.
Marginal zone lymphomas (MZL) encompass three sub-types: MALT (Mucosae Associated Lymphoid Tissue) MZL, nodal MZL and splenic MZL. Immunophenotyping is essential for accurate diagnosis. Helicobacter Pylori is frequently associated with gastric localizations and its eradication can be sufficient for cure. Treatment of nodal MZL is similar to that of follicular lymphoma. Eradication of hepatitis C virus, frequently associated with splenic MZL development, can be sufficient. Without HCV infection, splenectomy constitutes first line therapy. As other indolent lymphomas, disseminated MZL are incurable and treatment should be started only in symptomatic patients.
边缘区淋巴瘤(MZL)包括三种亚型:黏膜相关淋巴组织(MALT)型MZL、结内MZL和脾MZL。免疫表型分析对于准确诊断至关重要。幽门螺杆菌常与胃部病变相关,根除幽门螺杆菌可能足以治愈疾病。结内MZL的治疗与滤泡性淋巴瘤相似。丙型肝炎病毒的根除通常与脾MZL的发生相关,根除可能就足够了。若无丙型肝炎病毒感染,脾切除术是一线治疗方法。与其他惰性淋巴瘤一样,播散性MZL无法治愈,仅应对有症状的患者进行治疗。