Mondjinou Yawo A, Hyun Seok-Hee, Xiong Manxi, Collins Christopher J, Thong Pooi Ling, Thompson David H
Multi-disciplinary Cancer Research Facility, Bindley Bioscience Center, Department of Chemistry, Purdue University , 1203 West State Street, West Lafayette, Indiana 47907, United States.
ACS Appl Mater Interfaces. 2015 Nov 4;7(43):23831-6. doi: 10.1021/acsami.5b01016. Epub 2015 Oct 27.
Water-soluble polyrotaxanes have been prepared under heterogeneous conditions from mixtures of β-cyclodextrin (β-CD), 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), methyl-β-cyclodextrin, or 6-monoazido-β-cyclodextrin with 4-sulfobutyl ether-β-cyclodextrin (SBE-β-CD) and Pluronic L81 copolymer modified with cholesterol end caps. Threading reactions gave polyrotaxane products in modest chemical yield that were reflective of the β-CD feed ratios in the reaction. Polyrotaxanes containing mixtures of HP-β-CD and SBE-β-CD were screened and found to be biologically active in an in vitro model of Niemann-Pick Type C disease where they mobilize aberrantly stored cholesterol similarly to monomeric cyclodextrin controls.
水溶性聚轮烷是在非均相条件下,由β-环糊精(β-CD)、2-羟丙基-β-环糊精(HP-β-CD)、甲基-β-环糊精或6-单叠氮基-β-环糊精与4-磺丁基醚-β-环糊精(SBE-β-CD)以及用胆固醇封端修饰的普朗尼克L81共聚物的混合物制备而成。穿线反应得到的聚轮烷产物化学产率适中,这反映了反应中β-CD的进料比例。对含有HP-β-CD和SBE-β-CD混合物的聚轮烷进行了筛选,发现在尼曼-皮克C型病的体外模型中具有生物活性,在该模型中它们与单体环糊精对照物类似地动员异常储存的胆固醇。