Peptu Catalina A, Popa Marcel, Savin Corina, Popa Radu F, Ochiuz Lacramioara
Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, "Gheorghe Asachi" Technical University of Iasi, Professor dr. docent Dimitrie Mangeron Str, nr. 73, 700050 Iasi, Romania.
Curr Pharm Des. 2015;21(42):6055-69. doi: 10.2174/1381612821666151027151847.
Some of the most dangerous diseases of the eye are related to the posterior segment. Diseases such as age-related macular degeneration, cytomegalovirus retinitis, diabetic retinopathy, posterior uveitis and retinitis pigmentosa are difficult to treat using classical methods because of the many internal barriers of the eye which affect the drug efficiency. In this review, we will summarize the main research directions in the field of medicamentous treatment of posterior eye disorders belonging to the controlled drug delivery concept. The review is starting with the most important knowledge regarding anatomy and pathology of the posterior segment of the eye and is continuing with the current treatment methods of the eye posterior segment illnesses and drawbacks of these methods, the drugs administration pathways to the posterior segment of the eye. The last three sections present the state of the art regarding the latest discoveries including the commercial products in the modern drug delivery systems; the main classes of materials treated in the present review are implants, hydrogels and nano- microparticulate systems.
一些最危险的眼部疾病与眼后段有关。诸如年龄相关性黄斑变性、巨细胞病毒性视网膜炎、糖尿病性视网膜病变、后葡萄膜炎和色素性视网膜炎等疾病，由于眼睛存在许多影响药物疗效的内部屏障，使用传统方法难以治疗。在本综述中，我们将总结属于控释给药概念的眼后段疾病药物治疗领域的主要研究方向。综述首先介绍关于眼后段解剖学和病理学的最重要知识，接着阐述眼后段疾病的当前治疗方法以及这些方法的缺点、药物向眼后段的给药途径。最后三个部分介绍了包括现代给药系统中的商业产品在内的最新发现的现状；本综述所涉及的主要材料类别为植入物、水凝胶和纳米 - 微粒系统。
