原发性胆管癌患者术后体外照射：一项多中心回顾性研究

Postoperative External Irradiation of Patients with Primary Biliary Tract Cancer: A Multicenter Retrospective Study.

作者信息

Hayashi Kazuhiko, Isohashi Fumiaki, Ogawa Kazuhiko, Oikawa Hirobumi, Onishi Hiroshi, Ito Yoshinori, Takemoto Mitsuhiro, Karasawa Katsuyuki, Imai Michiko, Kosaka Yasuhiro, Yamazaki Hideya, Yoshioka Yasuo, Nemoto Kenji, Nishimura Yasumasa

机构信息

Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.

Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan

出版信息

Anticancer Res. 2015 Nov;35(11):6231-7.

PMID:26504056

Abstract

BACKGROUND/AIM: The aim of the present study was to assess clinical outcomes of postoperative radiotherapy for biliary tract cancer patients.

PATIENTS AND METHODS

Clinical results of 187 patients treated with external irradiation in 31 Japanese Institutions between 2000 and 2011 were retrospectively analyzed. The median radiation dose was 50.4 Gy in fractions of 1.8-2 Gy.

RESULTS

Two-year actuarial overall survival and locoregional control (LCs) rates were 56% and 68%, respectively. In multivariate analysis, macroscopic residual tumor (R2) and irradiated doses <54 Gy were significant indicators of poor LC prognosis. For patients with complete resection (R0) or microscopic residual tumor (R1), 2-year LCs were 71% for <54 Gy and 83% for ≥54 Gy; doses ≥54 Gy were associated with high long-term LCs. There was no significant difference in acute adverse event rates between <54 Gy and ≥54 Gy.

CONCLUSION

Postoperative irradiation doses of approximately 54 Gy are safe and effective for R0 or R1 resection patients.

摘要

背景/目的：本研究旨在评估胆道癌患者术后放疗的临床疗效。

患者与方法

回顾性分析了2000年至2011年间日本31家机构对187例患者进行外照射治疗的临床结果。中位放射剂量为50.4 Gy，每次分割剂量为1.8 - 2 Gy。

结果

两年精算总生存率和局部区域控制（LCs）率分别为56%和68%。多因素分析显示，肉眼残留肿瘤（R2）和照射剂量<54 Gy是LC预后不良的显著指标。对于完全切除（R0）或镜下残留肿瘤（R1）的患者，<54 Gy组2年LCs为71%，≥54 Gy组为83%；剂量≥54 Gy与较高的长期LCs相关。<54 Gy组和≥54 Gy组急性不良事件发生率无显著差异。