Department of Radiology, Graduate School of Medical Science University of the Ryukyus School of Medicine, 207 Uehara, Nishihara-cho, Okinawa, 903-0215, Japan.
Anticancer Res. 2013 May;33(5):2199-204.
To retrospectively analyze the treatment results of postoperative radiotherapy (PORT) in patients with early-stage uterine cervical cancer.
Records of 141 patients with stage IB-IIB uterine cervical cancer treated with PORT from 1985 to 2004 were retrospectively reviewed. The majority of patients received whole-pelvic radiotherapy with antero-posterior fields, and the total radiation doses ranged from 10.8-60 Gy (median: 50.4 Gy). The median follow-up of all 141 patients was 106 months (range: 0.8-273.7 months).
Multivariate analysis revealed that positive lymph node status (p=0.001) and histological type (p=0.015) were independent prognostic factors for overall survival. The group with three or more involved lymph nodes was significantly more likely to have extra-pelvic recurrence when compared with the groups with no (p=0.006) and up to two lymph nodes (p=0.024), respectively.
PORT yielded excellent pelvic control rates for early-stage uterine cervical cancer. Lymph node status and histological type were significant prognostic factors for overall survival of patients with these tumors.
回顾性分析早期宫颈癌患者术后放疗（PORT）的治疗效果。
回顾性分析了 1985 年至 2004 年间接受 PORT 治疗的 141 例ⅠB-ⅡB 期宫颈癌患者的记录。大多数患者接受前后野全盆腔放疗，总放射剂量为 10.8-60Gy（中位数：50.4Gy）。所有 141 例患者的中位随访时间为 106 个月（范围：0.8-273.7 个月）。
多因素分析显示，阳性淋巴结状态（p=0.001）和组织学类型（p=0.015）是总生存的独立预后因素。与无淋巴结（p=0.006）和最多两个淋巴结（p=0.024）受累的患者相比，有 3 个或更多淋巴结受累的患者发生盆腔外复发的可能性显著更高。
PORT 为早期宫颈癌提供了极佳的盆腔控制率。淋巴结状态和组织学类型是这些肿瘤患者总生存的显著预后因素。
