原位心脏移植术后曲霉菌性纵隔炎：一例报告
Aspergillus Mediastinitis after Orthotopic Heart Transplantation: A Case Report.
作者信息
El-Sayed Ahmed Magdy M, Almanfi Abdelkader, Aftab Muhammad, Singh Steve K, Mallidi Hari R, Frazier O H
出版信息
Tex Heart Inst J. 2015 Oct 1;42(5):468-70. doi: 10.14503/THIJ-14-4732. eCollection 2015 Oct.
A 55-year-old woman was admitted for orthotopic heart transplantation. Her medical history was notable for multiple cardiovascular problems, including ischemic cardiomyopathy that necessitated circulatory support with a left ventricular assist device. Five weeks after undergoing orthotopic heart transplantation, she developed Aspergillus calidoustus mediastinitis, for which she underwent a prolonged course of antifungal treatment that comprised (in sequence) posaconazole for 11 days, voriconazole for 10 days, and amphotericin B for 42 days. During this period, she also underwent repeated mediastinal drainage and sternal débridement, followed by sternal wiring and coverage with bilateral pectoralis advancement flaps. Four months postoperatively, she was discharged from the hospital with a successfully controlled infection and a healed sternum. To our knowledge, only 3 previous cases of Aspergillus mediastinitis after orthotopic heart transplantation have been reported in the literature, none of which was Aspergillus calidoustus.
一名55岁女性因原位心脏移植入院。她有多种心血管问题病史，包括缺血性心肌病，这需要使用左心室辅助装置进行循环支持。在接受原位心脏移植五周后，她患上了热栖曲霉纵隔炎，为此她接受了一个疗程较长的抗真菌治疗，依次包括泊沙康唑治疗11天、伏立康唑治疗10天以及两性霉素B治疗42天。在此期间，她还接受了多次纵隔引流和胸骨清创术，随后进行了胸骨钢丝固定，并采用双侧胸大肌推进皮瓣覆盖。术后四个月，她出院了，感染得到成功控制，胸骨愈合。据我们所知，文献中仅报道过3例原位心脏移植后发生曲霉纵隔炎的病例，均不是热栖曲霉。
Zotero 插件