新生大鼠出血性中风相关脑组织和血管中应激相关变化的光学监测。
Optical monitoring of stress-related changes in the brain tissues and vessels associated with hemorrhagic stroke in newborn rats.
作者信息
Semyachkina-Glushkovskaya Oxana, Pavlov Alexey, Kurths Jürgen, Borisova Ekaterina, Gisbrecht Alexander, Sindeeva Olga, Abdurashitov Arkady, Shirokov Alexander, Navolokin Nikita, Zinchenko Ekaterina, Gekalyuk Artem, Ulanova Maria, Zhu Dan, Luo Qingming, Tuchin Valery
机构信息
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia ; Huazhong University of Science and Technology, Wuhan 430074, China.
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
出版信息
Biomed Opt Express. 2015 Sep 24;6(10):4088-97. doi: 10.1364/BOE.6.004088. eCollection 2015 Oct 1.
Stress is a major factor for a risk of cerebrovascular catastrophes. Studying of mechanisms underlying stress-related brain-injures in neonates is crucial for development of strategy to prevent of neonatal stroke. Here, using a model of sound-stress-induced intracranial hemorrhages in newborn rats and optical methods, we found that cerebral veins are more sensitive to the deleterious effect of stress than arteries and microvessels. The development of venous insufficiency with decreased blood outflow from the brain accompanied by hypoxia, reduction of complexity of venous blood flow and high production of beta-arrestin-1 are possible mechanisms responsible for a risk of neonatal hemorrhagic stroke.
应激是脑血管灾难风险的一个主要因素。研究新生儿应激相关脑损伤的潜在机制对于制定预防新生儿中风的策略至关重要。在此，我们利用新生大鼠声音应激诱导颅内出血模型和光学方法，发现脑静脉比动脉和微血管对应激的有害作用更敏感。脑静脉功能不全的发展，伴有脑血流流出减少、缺氧、脑静脉血流复杂性降低以及β-抑制蛋白-1的高表达，可能是导致新生儿出血性中风风险的机制。
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