安非他酮和强力霉素引起的急性肝细胞药物性肝损伤。
Acute Hepatocellular Drug-Induced Liver Injury From Bupropion and Doxycycline.
作者信息
Tang Derek M, Koh Christopher, Twaddell William S, von Rosenvinge Erik C, Han Hyosun
机构信息
Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD ; Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
出版信息
ACG Case Rep J. 2015 Oct 9;3(1):66-8. doi: 10.14309/crj.2015.103. eCollection 2015 Oct.
The management and diagnosis of drug-induced liver injury (DILI) is often challenging, particularly when patients are taking multiple medications. We present a 29-year-old African American man who presented with jaundice and malaise after starting bupropion and doxycycline 2 weeks prior. He was found to have acute hepatocellular drug-induced liver injury with autoimmune features, and made a complete recovery with prednisone. Although bupropion and doxycycline are both known to cause liver toxicity, a closer inspection of the signature of liver injury and a review of prior related DILI cases assigns causality more to bupropion than doxycycline.
药物性肝损伤（DILI）的管理和诊断通常具有挑战性，尤其是当患者同时服用多种药物时。我们报告一名29岁的非裔美国男性，他在开始服用安非他酮和强力霉素2周后出现黄疸和不适。他被诊断为具有自身免疫特征的急性肝细胞性药物性肝损伤，使用泼尼松后完全康复。虽然安非他酮和强力霉素都已知会导致肝毒性，但通过对肝损伤特征的仔细检查以及对既往相关药物性肝损伤病例的回顾，发现安非他酮比强力霉素更可能是导致肝损伤的原因。
Zotero 插件