Lee Woo Jin, Lee Ye Jin, Lee Mi Hye, Won Chong Hyun, Chang Sung Eun, Choi Jee Ho, Lee Mi Woo
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
J Dermatol. 2016 May;43(5):526-31. doi: 10.1111/1346-8138.13166. Epub 2015 Oct 28.
Rosacea has a wide spectrum of clinical features, which include persistent facial redness, flushing, telangiectasia, inflammatory papules/pustules, hypertrophy and/or ocular features. The prognosis of rosacea according to clinical subtype has not been evaluated. We analyzed the prognosis of rosacea in 234 patients, which included 120 patients with mixed subtype, 75 with the erythematotelangiectatic rosacea subtype and 39 with the papulopustular rosacea (PPR) subtype. The prognosis of rosacea was classified as: (i) no improvement; (ii) partial remission; and (iii) complete remission. The frequencies of complete remission, time to complete remission and 1-year complete remission rate were compared between subtypes. Follow-up periods ranged 2-72 months (median follow-up, 17.5). Aggravation of the disease was found in 50.4% of patients during follow up. Partial or complete remission was noted in 61.5% and 20.9% of patients, respectively. The median time to complete remission was 56.0 months. The prognosis of disease was more favorable for patients with the PPR subtype than for patients with other subtypes with respect to the frequency of complete remission, median time to complete remission and the 2-year complete remission rate. In conclusion, papulopustular rosacea without remarkable centrofacial erythema showed a more favorable prognosis than other subtypes. Erythematotelangiectatic lesions in rosacea patients present a challenge for the treatment of rosacea.
酒渣鼻具有广泛的临床特征，包括持续性面部红斑、潮红、毛细血管扩张、炎性丘疹/脓疱、肥大和/或眼部特征。尚未评估酒渣鼻根据临床亚型的预后情况。我们分析了234例酒渣鼻患者的预后，其中包括120例混合亚型患者、75例红斑毛细血管扩张型酒渣鼻亚型患者和39例丘疹脓疱型酒渣鼻（PPR）亚型患者。酒渣鼻的预后分为：（i）无改善；（ii）部分缓解；（iii）完全缓解。比较了各亚型之间完全缓解的频率、完全缓解的时间和1年完全缓解率。随访期为2至72个月（中位随访时间为17.5个月）。在随访期间，50.4%的患者病情加重。分别有61.5%和20.9%的患者出现部分或完全缓解。完全缓解的中位时间为56.0个月。就完全缓解的频率、完全缓解的中位时间和2年完全缓解率而言，PPR亚型患者的疾病预后比其他亚型患者更有利。总之，无明显中央面部红斑的丘疹脓疱型酒渣鼻比其他亚型显示出更有利的预后。酒渣鼻患者的红斑毛细血管扩张性病变对酒渣鼻的治疗提出了挑战。
