Zhang Ning, Li Hong, Jia Jihui, He Mingqiang
Department of Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China.
Department of Microbiology, Key Laboratory for Experimental Teratology, Chinese Ministry of Education, School of Medicine, Shandong University, Jinan, Shandong 250012, China.
Cell Immunol. 2015 Nov-Dec;298(1-2):88-95. doi: 10.1016/j.cellimm.2015.09.010. Epub 2015 Sep 28.
Curcumin has commonly been used for the treatment of various allergic diseases. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In the present study, the effect of curcumin on allergic responses in ovalbumin (OVA)-induced allergic rhinitis mouse was investigated. We explored the effect of curcumin on the release of allergic inflammatory mediators, such as histamine, OVA-specific IgE, and inflammatory cytokines. Also, we found that curcumin improved rhinitis symptoms, inhibited the histopathological changes of nasal mucosa, and decreased the serum levels of histamine, OVA-specific IgE and TNF-α in OVA-induced allergic rhinitis mice. In addition, curcumin suppressed the production of inflammatory cytokines, such as TNF-α, IL-1β, IL-6 and IL-8. Moreover, curcumin significantly inhibited PMA-induced p-ERK, p-p38, p-JNK, p-Iκ-Bα and NF-κB. These findings suggest that curcumin has an anti-allergic effect through modulating mast cell-mediated allergic responses in allergic rhinitis, at least partly by inhibiting MAPK/NF-κB pathway.
姜黄素常用于治疗各种过敏性疾病。然而，其确切的抗过敏性鼻炎作用及机制尚不清楚。在本研究中，研究了姜黄素对卵清蛋白（OVA）诱导的过敏性鼻炎小鼠过敏反应的影响。我们探讨了姜黄素对组胺、OVA特异性IgE和炎性细胞因子等过敏炎性介质释放的影响。此外，我们发现姜黄素改善了鼻炎症状，抑制了鼻黏膜的组织病理学变化，并降低了OVA诱导的过敏性鼻炎小鼠血清中组胺、OVA特异性IgE和TNF-α的水平。另外，姜黄素抑制了TNF-α、IL-1β、IL-6和IL-8等炎性细胞因子的产生。此外，姜黄素显著抑制佛波酯（PMA）诱导的p-ERK、p-p38、p-JNK、p-Iκ-Bα和NF-κB。这些结果表明，姜黄素至少部分通过抑制MAPK/NF-κB途径，调节肥大细胞介导的过敏性鼻炎过敏反应，从而发挥抗过敏作用。
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