Rose Peter S, Morris Jonathan M
Department of Orthopedic Surgery-Gonda 14S, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Curr Rev Musculoskelet Med. 2015 Dec;8(4):353-60. doi: 10.1007/s12178-015-9307-6.
The field of cryosurgery began nearly 40 years ago with the open application of liquid nitrogen to ablate tumors. Recent developments in imaging and cryoprobe technology allow for percutaneous ablation of tumors. Computed tomography (CT)-guided cryoablation has particular use in treating musculoskeletal neoplasms because of the ability to image the lethal ice zone around both bone and soft tissue structures. This manuscript will review the development, indications, and results of cryoablation as applied to musculoskeletal neoplasms. This technique holds promise for the treatment of benign conditions as well as the palliation and durable treatment of musculoskeletal metastases; it is not commonly indicated in the curative treatment of primary malignant bone or soft tissue sarcomas.
冷冻外科领域始于近40年前,当时通过开放应用液氮来消融肿瘤。成像技术和冷冻探针技术的最新进展使得经皮肿瘤消融成为可能。计算机断层扫描(CT)引导下的冷冻消融在治疗肌肉骨骼肿瘤方面具有特殊用途,因为它能够对骨骼和软组织结构周围的致死性冰球区域进行成像。本文将综述应用于肌肉骨骼肿瘤的冷冻消融技术的发展、适应证及治疗结果。该技术有望用于治疗良性疾病以及缓解和持久治疗肌肉骨骼转移瘤;在原发性恶性骨或软组织肉瘤的根治性治疗中一般不常用。