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1例类风湿性脑膜炎以全身性癫痫发作为表现,其MRI图像有助于诊断

[A case of rheumatoid meningitis presented with generalized seizure in whom MRI images were helpful for the diagnosis].

作者信息

Yamashita Kazuya, Terasaki Yasukazu, Sakaguchi Manabu, Nakatsuji Yuji, Yoshizaki Kazuyuki, Mochizuki Hideki

机构信息

Department of Neurology, Osaka University Graduate School of Medicine.

出版信息

Rinsho Shinkeigaku. 2015;55(12):926-31. doi: 10.5692/clinicalneurol.cn-000773. Epub 2015 Oct 28.

Abstract

We report a 65-years-old woman with rheumatoid meningitis presented with a generalized seizure. She has a 18-year history of rheumatoid arthritis, which has been successfully treated. She developed a generalized seizure. She was diagnosed as having subarachnoid hemorrhage, because the brain magnetic resonance imaging (MRI) showed increased fluid attenuated inversion recovery (FLAIR) signals in her left frontoparietal subarachnoid space. After one month of clinical stabilization, she developed numbness and weakness in her right lower extremity that spread to her right upper extremity and face. Brain MRI showed progression of subarachnoid lesion on FLAIR image and leptomeningeal enhancement on gadolinium-enhanced T1 weighted image. She was diagnosed as having rheumatoid meningitis, and methylprednisolone pulse therapy was started. Then, her symptoms and MRI findings were rapidly improved. Though rheumatoid meningitis is rare and presents a difficulty in the diagnosis, MRI features may support the diagnosis.

摘要

我们报告了一位65岁患类风湿性脑膜炎并出现全身性癫痫发作的女性。她有18年类风湿性关节炎病史,此前病情已得到成功治疗。她出现了全身性癫痫发作。因脑磁共振成像(MRI)显示其左侧额顶叶蛛网膜下腔的液体衰减反转恢复(FLAIR)信号增强,她被诊断为蛛网膜下腔出血。临床稳定一个月后,她右下肢出现麻木和无力,并蔓延至右上肢和面部。脑部MRI显示FLAIR图像上蛛网膜下腔病变进展,钆增强T1加权图像上软脑膜强化。她被诊断为类风湿性脑膜炎,并开始使用甲泼尼龙脉冲疗法。随后,她的症状和MRI表现迅速改善。尽管类风湿性脑膜炎罕见且诊断困难,但MRI特征可能有助于诊断。

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