Matsukura Mitsuru, Hoshina Katsuyuki, Shigematsu Kunihiro, Miyata Tetsuro, Watanabe Toshiaki
Department of Vascular Surgery, The University of Tokyo.
Circ J. 2016;80(1):235-42. doi: 10.1253/circj.CJ-15-0704. Epub 2015 Oct 29.
The aim of this study was to evaluate the usefulness of paramalleolar arterial Bollinger score (PBS) for predicting postoperative outcome of infra-popliteal bypass surgery for critical limb ischemia (CLI).
A total of 104 consecutive patients (118 limbs) who underwent infra-popliteal (tibial or paramalleolar) arterial bypass surgery with an autologous vein conduit for the treatment of CLI (Rutherford 4-6) between January 2002 and December 2012 were classified according to PBS ≤45 or >45. Postoperative outcome was compared between these groups. Primary outcomes were major adverse limb events plus perioperative death, and amputation-free survival (AFS). The secondary outcomes were overall survival, limb salvage and secondary graft patency. More than 80% of patients had either diabetes mellitus (DM) or end-stage renal disease (ESRD) and 30 patients with 36 limbs had PBS >45. Compared with the PBS ≤45 group, the PBS >45 group had higher CVD and carotid stenosis rate, poor nutrition status and lower malignancy rate. On overall analysis, the PBS >45 group had worse outcome for AFS and survival but this was not statistically significant (P=0.12, NS). In DM or ESRD patients, the PBS >45 group had significantly worse outcome for both AFS (P=0.04, 0.02) and overall survival rate (P=0.04, 0.03).
PBS successfully classified CLI patients with DM or ESRD who had worse outcome after infra-popliteal bypass surgery.
本研究旨在评估踝周动脉博林格评分(PBS)对预测严重肢体缺血(CLI)患者腘动脉以下旁路手术术后结局的有效性。
2002年1月至2012年12月期间,共有104例连续患者(118条肢体)接受了自体静脉移植的腘动脉以下(胫动脉或踝周动脉)动脉旁路手术以治疗CLI(卢瑟福分级4 - 6级),根据PBS≤45或>45进行分组。比较两组的术后结局。主要结局为主要不良肢体事件加围手术期死亡以及无截肢生存率(AFS)。次要结局为总生存率、肢体挽救率和移植血管二次通畅率。超过80%的患者患有糖尿病(DM)或终末期肾病(ESRD),30例患者(36条肢体)的PBS>45。与PBS≤45组相比,PBS>45组的心血管疾病(CVD)和颈动脉狭窄率更高,营养状况较差,恶性肿瘤发生率更低。总体分析显示,PBS>45组的AFS和生存率结局较差,但差异无统计学意义(P = 0.12,无显著性差异)。在DM或ESRD患者中,PBS>45组的AFS(P = 0.04,0.02)和总生存率(P = 0.04,0.03)均显著较差。
PBS成功地对DM或ESRD的CLI患者进行了分类,这些患者在腘动脉以下旁路手术后结局较差。