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糖尿病和终末期肾病时代的踝关节旁动脉博林格评分——对预测严重肢体缺血手术结果的实用性

Paramalleolar Arterial Bollinger Score in the Era of Diabetes and End-Stage Renal Disease - Usefulness for Predicting Operative Outcome of Critical Limb Ischemia.

作者信息

Matsukura Mitsuru, Hoshina Katsuyuki, Shigematsu Kunihiro, Miyata Tetsuro, Watanabe Toshiaki

机构信息

Department of Vascular Surgery, The University of Tokyo.

出版信息

Circ J. 2016;80(1):235-42. doi: 10.1253/circj.CJ-15-0704. Epub 2015 Oct 29.

Abstract

BACKGROUND

The aim of this study was to evaluate the usefulness of paramalleolar arterial Bollinger score (PBS) for predicting postoperative outcome of infra-popliteal bypass surgery for critical limb ischemia (CLI).

METHODS AND RESULTS

A total of 104 consecutive patients (118 limbs) who underwent infra-popliteal (tibial or paramalleolar) arterial bypass surgery with an autologous vein conduit for the treatment of CLI (Rutherford 4-6) between January 2002 and December 2012 were classified according to PBS ≤45 or >45. Postoperative outcome was compared between these groups. Primary outcomes were major adverse limb events plus perioperative death, and amputation-free survival (AFS). The secondary outcomes were overall survival, limb salvage and secondary graft patency. More than 80% of patients had either diabetes mellitus (DM) or end-stage renal disease (ESRD) and 30 patients with 36 limbs had PBS >45. Compared with the PBS ≤45 group, the PBS >45 group had higher CVD and carotid stenosis rate, poor nutrition status and lower malignancy rate. On overall analysis, the PBS >45 group had worse outcome for AFS and survival but this was not statistically significant (P=0.12, NS). In DM or ESRD patients, the PBS >45 group had significantly worse outcome for both AFS (P=0.04, 0.02) and overall survival rate (P=0.04, 0.03).

CONCLUSIONS

PBS successfully classified CLI patients with DM or ESRD who had worse outcome after infra-popliteal bypass surgery.

摘要

背景

本研究旨在评估踝周动脉博林格评分(PBS)对预测严重肢体缺血(CLI)患者腘动脉以下旁路手术术后结局的有效性。

方法与结果

2002年1月至2012年12月期间,共有104例连续患者(118条肢体)接受了自体静脉移植的腘动脉以下(胫动脉或踝周动脉)动脉旁路手术以治疗CLI(卢瑟福分级4 - 6级),根据PBS≤45或>45进行分组。比较两组的术后结局。主要结局为主要不良肢体事件加围手术期死亡以及无截肢生存率(AFS)。次要结局为总生存率、肢体挽救率和移植血管二次通畅率。超过80%的患者患有糖尿病(DM)或终末期肾病(ESRD),30例患者(36条肢体)的PBS>45。与PBS≤45组相比,PBS>45组的心血管疾病(CVD)和颈动脉狭窄率更高,营养状况较差,恶性肿瘤发生率更低。总体分析显示,PBS>45组的AFS和生存率结局较差,但差异无统计学意义(P = 0.12,无显著性差异)。在DM或ESRD患者中,PBS>45组的AFS(P = 0.04,0.02)和总生存率(P = 0.04,0.03)均显著较差。

结论

PBS成功地对DM或ESRD的CLI患者进行了分类,这些患者在腘动脉以下旁路手术后结局较差。

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