Glezerman M, Lunenfeld E, Doerner T, Cohen V, Sarov I, Revel M
Harefuah. 1989 Jan 15;116(2):88-90.
19 women and 9 men, aged 15-59 (mean, 35.1), who had had recurrent lip or genital infections with herpes virus (HSV) for from 1-38 years, were treated with beta-interferon gel (100,000 IU/g), self-administered 4 times daily to the affected areas. In half the patients the drug and a placebo were given in a double-blind, cross-over study. The trial lasted 30 months. Frequency of attacks, length of each attack and its severity, and the presence of itching were noted. If there was improvement in at least 2 parameters treatment was considered successful. This was the case in about 75% of the patients. The mean number of attacks per year before and during treatment with interferon was 6.8 and 3.0, respectively (p less than 0.003) and the mean length of attacks 8.2 and 4.7 days, respectively (p less than 0.001). Results of the double-blind, cross-over test were also significant, and were similar to those for the total group. These results clearly indicate that local interferon is effective treatment for genital and labial HSV infections.
19名女性和9名男性，年龄在15至59岁之间（平均35.1岁），患有复发性唇或生殖器疱疹病毒（HSV）感染1至38年，用β-干扰素凝胶（100,000国际单位/克）治疗，患者自行将药物每日4次涂抹于患处。在一半患者中，药物和安慰剂在双盲交叉研究中给予。试验持续30个月。记录发作频率、每次发作的时长及其严重程度以及瘙痒情况。如果至少2个参数有所改善，则认为治疗成功。约75%的患者属于这种情况。干扰素治疗前和治疗期间每年的平均发作次数分别为6.8次和3.0次（p<0.003），平均发作时长分别为8.2天和4.7天（p<0.001）。双盲交叉试验结果也很显著，与整个组的结果相似。这些结果清楚地表明，局部使用干扰素是治疗生殖器和唇部HSV感染的有效方法。
